{"id":"W2765962978","doi":"10.1002/hep.29621","title":"Safety, tolerability, and pharmacokinetics of l‐ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia","year":2017,"lang":"en","type":"article","venue":"Hepatology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of South Carolina; University of Texas Southwestern Medical Center; Virginia Commonwealth University; Northwestern University; Ohio State University; University of Alberta; Emory University; University of California, San Francisco; Massachusetts General Hospital","keywords":"Medicine; Tolerability; Hyperammonemia; Phenylacetate; Interquartile range; Pharmacokinetics; Adverse effect; Gastroenterology; Internal medicine; Excretion; Urology; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008494042,0.0002560308,0.0006114592,0.0001158391,0.0001920311,0.0003869271,0.0001392859,0.0002674915,0.0003799175],"category_scores_gemma":[0.001511917,0.0001341905,0.0004251777,0.0001875074,0.0002691551,0.0003076014,0.0001555482,0.0005809814,0.0001402812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002711978,"about_ca_system_score_gemma":0.0002557152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003141802,"about_ca_topic_score_gemma":0.0003867534,"domain_scores_codex":[0.9996666,0.0001725802,0.00003807024,0.00003421442,0.00005098016,0.00003765711],"domain_scores_gemma":[0.9989813,0.0002458247,0.000456278,0.00005194754,0.00006313378,0.0002016191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2684121,0.007002896,0.4183549,0.0005920118,0.001102506,0.001620344,0.0009330566,0.003115044,0.06917656,0.0001514281,0.001410266,0.2281289],"study_design_scores_gemma":[0.01135365,0.3295794,0.6396797,0.0000714817,0.000699495,0.00204709,0.0003927956,0.003917005,0.009790939,0.0001500249,0.002265333,0.00005308119],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988965,0.000680311,0.0001271878,0.00004807419,0.000003860404,0.0000182328,0.00003391341,0.000007651018,0.0001843584],"genre_scores_gemma":[0.9994649,0.0002199434,0.00009692153,0.00007644854,0.00001360352,0.00001787306,0.00005341995,0.000001539285,0.00005527723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008494042,"threshold_uncertainty_score":0.004492164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00449511252036519,"score_gpt":0.2326265579087941,"score_spread":0.2281314453884289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}