{"id":"W2765978966","doi":"10.1042/bcj20170648","title":"<i>TSPO</i>mutations in rats and a human polymorphism impair the rate of steroid synthesis","year":2017,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; Medical Research Council; National Institute for Health and Care Research","keywords":"Translocator protein; Steroid; Biology; Steroid biosynthesis; Endocrinology; Neuroactive steroid; Internal medicine; Cholesterol; Steroid hormone; Gene; Mitochondrion; Hormone; Biochemistry; Receptor; Inflammation; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001470729,0.00100963,0.000329669,0.0007613683,0.0003288723,0.0001931268,0.0002970066,0.0005759117,0.005834443],"category_scores_gemma":[0.0003335922,0.0002515765,0.0005951016,0.0003250582,0.0007120445,0.0001280447,0.0004253794,0.000548005,0.0006881576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997962,"about_ca_system_score_gemma":0.0002515899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001700696,"about_ca_topic_score_gemma":0.001647712,"domain_scores_codex":[0.9996369,0.00008509574,0.00005112968,0.0001095577,0.00006679872,0.00005048915],"domain_scores_gemma":[0.9995331,0.00006620453,0.0002143921,0.00004290655,0.00002137297,0.0001221224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001562088,0.000197542,0.002844879,0.0000774843,0.0001400092,0.003642631,0.00009269429,0.0001529298,0.9862498,0.0005495772,0.000250047,0.004240389],"study_design_scores_gemma":[0.001070153,0.005919377,0.2213859,0.0001569265,0.001362753,0.06490356,0.0006640498,0.003551777,0.6779335,0.001582764,0.02126309,0.0002062465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943271,0.0002981407,0.003128377,0.0001626278,0.00006975298,0.00003470047,0.0009366453,0.0001105995,0.0009321913],"genre_scores_gemma":[0.9937874,0.0003851302,0.002534107,0.0001084268,0.0000577552,0.00005369374,0.0008969522,0.0001293296,0.002047158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005834443,"threshold_uncertainty_score":0.01951814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636837402125315,"score_gpt":0.2751502877565904,"score_spread":0.2587819137353373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}