{"id":"W2766005809","doi":"10.1016/j.jalz.2017.06.1827","title":"[P3–014]: INVESTIGATION OF PHARMACOKINETIC DRUG‐DRUG INTERACTION FOLLOWING ORAL ADMINISTRATION OF BI 409306 AND DONEPEZIL IN HEALTHY SUBJECTS","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Donepezil; Cmax; Pharmacokinetics; Pharmacology; Crossover study; Medicine; Area under the curve; Adverse effect; Internal medicine; Dementia; Disease; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007691141,0.0007216006,0.0009891494,0.0002100705,0.0005080364,0.0003323203,0.0005561761,0.001382542,0.005446226],"category_scores_gemma":[0.0007701801,0.0003237999,0.0006669899,0.0002924555,0.0003555118,0.0004219655,0.0002240858,0.001232992,0.001180996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002969489,"about_ca_system_score_gemma":0.001161644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002603408,"about_ca_topic_score_gemma":0.002672545,"domain_scores_codex":[0.9996741,0.00009802001,0.00002332949,0.00009414454,0.00004880862,0.00006155195],"domain_scores_gemma":[0.9995984,0.00005289814,0.00006222933,0.00004313626,0.00006600769,0.0001772976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4108532,0.06488258,0.01572902,0.0007805952,0.00121721,0.002138273,0.0005180195,0.001345517,0.3390598,0.0005286909,0.008619734,0.1543275],"study_design_scores_gemma":[0.04892965,0.816619,0.07367864,0.00004754056,0.0006856389,0.001985931,0.0001811517,0.00297795,0.04276403,0.0002922763,0.01176059,0.00007768769],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938865,0.0004043494,0.0008232511,0.0002408325,0.0001055984,0.001098629,0.000859431,0.0000799996,0.002501472],"genre_scores_gemma":[0.9880364,0.0004058705,0.002480469,0.001004565,0.000106083,0.001019268,0.00164612,0.00003130576,0.005269994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005446226,"threshold_uncertainty_score":0.01821941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0533879881702957,"score_gpt":0.3586905857963192,"score_spread":0.3053025976260235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}