{"id":"W2766012717","doi":"10.1126/scitranslmed.aao4583","title":"Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients","year":2017,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"British Heart Foundation","keywords":"Medicine; Pyruvate kinase; Pulmonary hypertension; Pyruvate dehydrogenase kinase; Cardiology; Pyruvate dehydrogenase complex; Genetically modified organism; Internal medicine; Hemodynamics; Pharmacology; Enzyme; Endocrinology; Gene; Biology; Glycolysis; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002715455,0.0005531563,0.0005045973,0.000168399,0.0001415212,0.0002794144,0.0001406019,0.0003496242,0.001105126],"category_scores_gemma":[0.000370405,0.00008616713,0.0003060189,0.0001123723,0.00020536,0.0002195013,0.000149736,0.001005714,0.0001729613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083764,"about_ca_system_score_gemma":0.0001875414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001241428,"about_ca_topic_score_gemma":0.0002883751,"domain_scores_codex":[0.9998875,0.00003404198,0.00001169507,0.00001720924,0.00003079477,0.00001880428],"domain_scores_gemma":[0.9998341,0.00003817279,0.00004686002,0.00001738797,0.000009049641,0.00005443026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02989809,0.005376179,0.03171784,0.0002694936,0.0005778418,0.003540525,0.0001069498,0.001349265,0.7624462,0.001474271,0.002667847,0.1605754],"study_design_scores_gemma":[0.01673846,0.1386931,0.308149,0.0001444498,0.001340252,0.02057463,0.0002889405,0.008216039,0.4822988,0.004008492,0.01944242,0.000105319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914616,0.002396877,0.002188911,0.0007150398,0.0001376718,0.00007228757,0.0001956684,0.0001845048,0.002647363],"genre_scores_gemma":[0.9977469,0.0006305166,0.0007190984,0.0002028036,0.00004324433,0.00001758392,0.0001978219,0.000007998818,0.0004340721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001105126,"threshold_uncertainty_score":0.003697038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175691611842493,"score_gpt":0.3049696892277056,"score_spread":0.2732127731092806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}