{"id":"W2766016615","doi":"10.1038/s41598-017-14754-6","title":"Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Division of Materials Research; National Institute of General Medical Sciences; National Synchrotron Radiation Research Center; Novartis Pharma; Ontario Genomics Institute; National Science Foundation; Duke-NUS Medical School; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Ontario Research Foundation; Wellcome Trust; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; U.S. Department of Energy; Pfizer","keywords":"Kinesin; Centrosome; Microtubule; Mitosis; Motor protein; Cell biology; Binding site; Spindle apparatus; Biology; Tubulin; ATPase; Chemistry; Computational biology; Cell division; Gene; Biochemistry; Enzyme; Cell; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007037335,0.0002119468,0.000209411,0.00009378551,0.0001596382,0.0001449356,0.0003401536,0.0002060312,0.001340449],"category_scores_gemma":[0.0001451181,0.0001340244,0.0001551344,0.00008514239,0.0001627332,0.0001169561,0.00009356514,0.0002706796,0.0002492732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004164808,"about_ca_system_score_gemma":0.0002810117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002711223,"about_ca_topic_score_gemma":0.002408403,"domain_scores_codex":[0.999904,0.000009968659,0.000005498428,0.00001768372,0.0000471969,0.00001561561],"domain_scores_gemma":[0.9999484,0.00001111078,0.00001724463,0.000003409816,0.00001028824,0.000009507649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001730382,0.00006000114,0.0005686209,0.0000522497,0.00002311554,0.0001594099,0.00001163854,0.001870308,0.9933112,0.0003869185,0.0002060392,0.00317764],"study_design_scores_gemma":[0.00007898057,0.0003083292,0.005721151,0.000006103759,0.00003589969,0.0003710093,0.0000161929,0.008347888,0.9815092,0.0001230888,0.003473166,0.000008926566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916975,0.001908761,0.002550415,0.000197951,0.00002957742,0.0000307402,0.0003032479,0.00009648053,0.003185282],"genre_scores_gemma":[0.9966013,0.0005827963,0.001292525,0.00007090284,0.000004100922,0.00001163461,0.0003495068,0.000009475391,0.001077722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002711223,"threshold_uncertainty_score":0.005390882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133328385544285,"score_gpt":0.2461554055025441,"score_spread":0.2328225669481157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}