{"id":"W2766056404","doi":"10.1016/j.gene.2017.10.044","title":"CRELD1 gene variants and atrioventricular septal defects in Down syndrome","year":2017,"lang":"en","type":"article","venue":"Gene","topic":"Cardiac Structural Anomalies and Repair","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Department of Science and Technology, Government of Kerala; Ministry of Health, British Columbia","keywords":"Biology; Atrioventricular Septal Defect; Gene; Genetics; NFAT; Down syndrome; Calcineurin; Transcription factor; Internal medicine; Heart disease; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003345269,0.001059046,0.0005409868,0.001929016,0.0005198499,0.0006589024,0.0007894735,0.001770023,0.005331831],"category_scores_gemma":[0.002275713,0.0003306274,0.0005201314,0.0008357773,0.0007415737,0.0006014809,0.0006226639,0.0007329936,0.0004053884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002525729,"about_ca_system_score_gemma":0.0002877421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002026769,"about_ca_topic_score_gemma":0.00137239,"domain_scores_codex":[0.9994686,0.00007976653,0.0000860254,0.0001499064,0.0001306883,0.00008502707],"domain_scores_gemma":[0.9991342,0.0003784539,0.0002322436,0.00004301966,0.00005753302,0.0001545121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003390499,0.0002972888,0.4692593,0.0002384281,0.0005233632,0.3616753,0.001901888,0.0008163201,0.1356254,0.00322696,0.001509703,0.02153553],"study_design_scores_gemma":[0.0002896089,0.0004685434,0.5300094,0.0002217978,0.001201684,0.4291893,0.001264918,0.002582199,0.02524729,0.002149433,0.007258012,0.0001178565],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952061,0.001262226,0.0006820984,0.0003558607,0.00007194147,0.00001131371,0.0003997176,0.00002121661,0.001989571],"genre_scores_gemma":[0.9978849,0.0003596277,0.0004978416,0.00009432244,0.00006584616,0.00000575082,0.0002012124,0.0000144252,0.0008758307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005331831,"threshold_uncertainty_score":0.01783681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007941320752578815,"score_gpt":0.2386488691663363,"score_spread":0.2307075484137575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}