{"id":"W2766107001","doi":"10.1016/j.omtm.2017.10.004","title":"Production and Purification of High-Titer Newcastle Disease Virus for Use in Preclinical Mouse Models of Cancer","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"Oncolytic virus; Newcastle disease; Embryonated; Virus; Virology; Titer; Biology; Mononegavirales; Microbiology; Paramyxoviridae; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001221091,0.001047689,0.0006748121,0.001266491,0.0004894632,0.0008063813,0.0009810438,0.001023559,0.002215311],"category_scores_gemma":[0.0005418938,0.00060775,0.000767816,0.0005005589,0.0004217132,0.0005872997,0.0005993793,0.002093561,0.002365988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008060791,"about_ca_system_score_gemma":0.0007314417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008279047,"about_ca_topic_score_gemma":0.001756864,"domain_scores_codex":[0.9990452,0.0001707663,0.0001385849,0.0001504012,0.0003693297,0.0001257329],"domain_scores_gemma":[0.9994863,0.00005864233,0.0001007393,0.0001328343,0.0001048876,0.0001166455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008785306,0.000116076,0.00009447026,0.0001073982,0.00001261881,0.0000426782,0.00003285409,0.0002131872,0.994866,0.0005004,0.0004329174,0.003493523],"study_design_scores_gemma":[0.00005763554,0.0004562774,0.0006469761,0.00003085921,0.00002984315,0.000226386,0.00001210268,0.0009857401,0.9755434,0.0001490586,0.02184276,0.00001883638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3460566,0.0101944,0.5990959,0.001099936,0.0009533636,0.009471478,0.01364074,0.003734173,0.01575344],"genre_scores_gemma":[0.3991613,0.01200102,0.5272364,0.0004722572,0.0001686037,0.007076941,0.02386607,0.0009387229,0.02907865],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002215311,"threshold_uncertainty_score":0.007411003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.225310428922894,"score_gpt":0.503903824089291,"score_spread":0.278593395166397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}