{"id":"W2766107001","doi":"10.1016/j.omtm.2017.10.004","title":"Production and Purification of High-Titer Newcastle Disease Virus for Use in Preclinical Mouse Models of Cancer","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"Oncolytic virus; Newcastle disease; Embryonated; Virus; Virology; Titer; Biology; Mononegavirales; Microbiology; Paramyxoviridae; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002973351,0.0001874994,0.0004016729,0.00007301889,0.00008433699,0.00003214016,0.0003521628,0.0001993341,0.000008987898],"category_scores_gemma":[0.001302019,0.0001706459,0.0001464466,0.0000550642,0.0002805086,0.00001998671,0.0001374552,0.0001382582,4.521752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002093871,"about_ca_system_score_gemma":0.000336721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008879062,"about_ca_topic_score_gemma":0.0002280759,"domain_scores_codex":[0.9973647,0.0006533537,0.0008663067,0.000658199,0.0002150552,0.0002424122],"domain_scores_gemma":[0.9980953,0.0001336752,0.0004103861,0.0009391244,0.0002736731,0.0001478134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008153461,0.0004619876,0.009066949,0.0000472328,0.0001944157,0.00000103615,0.00006072355,0.0003620934,0.7288137,0.00004323973,0.00002423537,0.2527709],"study_design_scores_gemma":[0.001686062,0.0007081807,0.04501847,0.0000457077,0.00001938619,2.341687e-7,0.000004794717,0.0004065899,0.9494308,0.0009753823,0.001504941,0.0001994938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9461431,0.001765049,0.0506249,0.0003518405,0.0001545176,0.0009217179,0.00002978155,0.000005245455,0.000003862946],"genre_scores_gemma":[0.7601912,0.004473134,0.2343806,0.0001811565,0.00007863319,0.0003419291,0.00004983449,0.00004586656,0.0002575936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2525714,"threshold_uncertainty_score":0.6958736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.225310428922894,"score_gpt":0.503903824089291,"score_spread":0.278593395166397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}