{"id":"W2766123956","doi":"10.1021/acsinfecdis.7b00145","title":"Polymyxin B<sub>3</sub>–Tobramycin Hybrids with <i>Pseudomonas aeruginosa</i>-Selective Antibacterial Activity and Strong Potentiation of Rifampicin, Minocycline, and Vancomycin","year":2017,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Manitoba Health Research Council","keywords":"Tobramycin; Polymyxin; Pseudomonas aeruginosa; Minocycline; Vancomycin; Rifampicin; Microbiology; Antibacterial agent; Polymyxin B; Long-term potentiation; Antibiotics; Aminoglycoside; Medicine; Pharmacology; Biology; Gentamicin; Bacteria; Staphylococcus aureus; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071817,0.0003312638,0.0001644866,0.00008569343,0.00009054672,0.0002054243,0.0001579088,0.0002823715,0.000953669],"category_scores_gemma":[0.0001397598,0.0001280713,0.0001980686,0.0001300048,0.0001603465,0.0002216297,0.000198236,0.000447969,0.0002957913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392494,"about_ca_system_score_gemma":0.000112657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002839134,"about_ca_topic_score_gemma":0.0003879156,"domain_scores_codex":[0.9998866,0.00002831974,0.000007658485,0.00002221786,0.00002378567,0.00003136785],"domain_scores_gemma":[0.9998846,0.00001711727,0.00005351633,0.0000112597,0.000009801208,0.00002370684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003590715,0.0000100507,0.00007733638,0.00001085433,0.000003811945,0.00001427887,0.000004573069,0.00006556409,0.9992281,0.00004809588,0.00001390445,0.0004875473],"study_design_scores_gemma":[0.000005991292,0.0001425695,0.0009635411,0.000002128452,0.000009128506,0.00008763236,0.000008390908,0.0002997039,0.9975315,0.00001766734,0.0009289922,0.000002649576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943427,0.0006469971,0.00367899,0.00006285556,0.00001625648,0.00001897227,0.00008010152,0.00005741875,0.001095735],"genre_scores_gemma":[0.9960039,0.0001957157,0.002689587,0.00004680979,0.000004204829,0.0000150981,0.0001516863,0.00002110215,0.0008718618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000953669,"threshold_uncertainty_score":0.003190339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00476386191939531,"score_gpt":0.2285703836150787,"score_spread":0.2238065216956834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}