{"id":"W2766123956","doi":"10.1021/acsinfecdis.7b00145","title":"Polymyxin B<sub>3</sub>–Tobramycin Hybrids with <i>Pseudomonas aeruginosa</i>-Selective Antibacterial Activity and Strong Potentiation of Rifampicin, Minocycline, and Vancomycin","year":2017,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Manitoba Health Research Council","keywords":"Tobramycin; Polymyxin; Pseudomonas aeruginosa; Minocycline; Vancomycin; Rifampicin; Microbiology; Antibacterial agent; Polymyxin B; Long-term potentiation; Antibiotics; Aminoglycoside; Medicine; Pharmacology; Biology; Gentamicin; Bacteria; Staphylococcus aureus; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008167508,0.0002661445,0.0003171211,0.00005847374,0.0003251646,0.0001307316,0.0001415191,0.0001294224,0.000002367472],"category_scores_gemma":[0.0001937331,0.0002458669,0.00005870827,0.00004465522,0.0004417129,0.00005286047,0.0001636256,0.00009276356,6.871794e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002047499,"about_ca_system_score_gemma":0.000103065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001821963,"about_ca_topic_score_gemma":0.0004060758,"domain_scores_codex":[0.9987911,0.00008345401,0.0002069759,0.0005038645,0.0001466898,0.0002679152],"domain_scores_gemma":[0.9987888,0.00003586888,0.0004024076,0.0005156682,0.0001316095,0.0001256497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004335294,0.0001077799,0.4643254,0.00004554781,0.00009715273,0.000004612913,0.000009450965,0.000002766343,0.5314164,0.00002262519,0.00005577904,0.003478935],"study_design_scores_gemma":[0.0009692426,0.0003288749,0.5717993,0.000035243,0.00009174087,0.00002187253,0.00001298678,0.000007434716,0.4264831,0.00005521557,0.0000225963,0.0001723718],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980988,0.0002768236,0.000679625,0.00003560138,0.0001839906,0.0003123596,0.0001412965,0.00002321524,0.0002482805],"genre_scores_gemma":[0.999018,0.0005043318,0.00006713323,0.00003285937,0.0002448418,0.000008816273,0.00007254336,0.00003211856,0.0000193736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1074739,"threshold_uncertainty_score":0.9999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00476386191939531,"score_gpt":0.2285703836150787,"score_spread":0.2238065216956834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}