{"id":"W2766135956","doi":"10.1021/acs.molpharmaceut.7b00529","title":"<i>In Vitro</i> Dissolution, Cellular Membrane Permeability, and Anti-Inflammatory Response of Resveratrol-Encapsulated Mesoporous Silica Nanoparticles","year":2017,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Universität Wien; Fonds de recherche du Québec – Nature et technologies; University of Queensland","keywords":"Resveratrol; Nanocarriers; Mesoporous silica; Nanoparticle; Chemistry; Solubility; Mesoporous material; Particle size; Chemical engineering; Nanocapsules; Chromatography; Nanotechnology; Materials science; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745468,0.0003060805,0.0001447752,0.000136808,0.00009278274,0.0001221315,0.0001295159,0.0002235926,0.0006515122],"category_scores_gemma":[0.0001713986,0.0001012419,0.0002882542,0.00007768383,0.000159552,0.0001692093,0.00008067524,0.00023079,0.0002477785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001910192,"about_ca_system_score_gemma":0.0001002692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008702591,"about_ca_topic_score_gemma":0.0009461602,"domain_scores_codex":[0.9998941,0.00002098548,0.00001227207,0.00002126908,0.00003044564,0.0000209254],"domain_scores_gemma":[0.9998977,0.00003083032,0.00003465688,0.0000109159,0.00001850131,0.000007367535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006748258,0.000009118206,0.00006108555,0.0000222451,0.00000428957,0.00001796316,0.000007669254,0.00007223361,0.9993293,0.00002367953,0.00001864294,0.0003662575],"study_design_scores_gemma":[0.000001278347,0.0000845589,0.0004514453,0.000001049762,0.000003604979,0.00001758804,0.00000289889,0.0002934461,0.9989517,0.000004652807,0.0001864264,0.000001334477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937489,0.001512666,0.002731419,0.00005918436,0.00002529924,0.0000186816,0.0002751007,0.0000697172,0.001558996],"genre_scores_gemma":[0.995904,0.0005885187,0.001713728,0.00002475103,0.00000963517,0.00001742798,0.0003590662,0.00001846199,0.001364445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008702591,"threshold_uncertainty_score":0.002179503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243458306990927,"score_gpt":0.2941156344956461,"score_spread":0.2816810514257368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}