{"id":"W2766135956","doi":"10.1021/acs.molpharmaceut.7b00529","title":"<i>In Vitro</i> Dissolution, Cellular Membrane Permeability, and Anti-Inflammatory Response of Resveratrol-Encapsulated Mesoporous Silica Nanoparticles","year":2017,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Universität Wien; Fonds de recherche du Québec – Nature et technologies; University of Queensland","keywords":"Resveratrol; Nanocarriers; Mesoporous silica; Nanoparticle; Chemistry; Solubility; Mesoporous material; Particle size; Chemical engineering; Nanocapsules; Chromatography; Nanotechnology; Materials science; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007554493,0.000222269,0.0002638601,0.00006577428,0.0002079337,0.00004626856,0.000440574,0.0002023954,0.00001498608],"category_scores_gemma":[0.0003618364,0.0002341752,0.00009626978,0.000101426,0.0007252224,0.00001473735,0.0003688053,0.0001675512,0.000005749937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002603882,"about_ca_system_score_gemma":0.0001086992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002307737,"about_ca_topic_score_gemma":0.0000040287,"domain_scores_codex":[0.9981812,0.0002324514,0.000447933,0.0005075441,0.0002707849,0.0003600507],"domain_scores_gemma":[0.9983971,0.00003293994,0.0002159756,0.001017667,0.0001264924,0.0002098619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005812565,0.0001815413,0.001549415,0.0000585536,0.00005067692,0.00004902896,0.00006583129,0.00003118592,0.99694,0.00007342685,0.0001042769,0.0003148484],"study_design_scores_gemma":[0.001321852,0.00005896364,0.003834969,0.0000119228,0.00005191788,0.00002153071,0.00002217881,0.0007003746,0.9841178,0.0001129159,0.009512532,0.0002330635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959648,0.001281878,0.0002724807,0.001845667,0.00007987348,0.0004001498,0.00006323559,0.00001683837,0.00007508268],"genre_scores_gemma":[0.9988589,0.0002124499,0.0004039776,0.0002761495,0.00005040687,0.00003487055,0.00004508778,0.00003312586,0.00008500304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01282218,"threshold_uncertainty_score":0.9549388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243458306990927,"score_gpt":0.2941156344956461,"score_spread":0.2816810514257368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}