{"id":"W2766136317","doi":"10.1253/circj.cj-17-0585","title":"Ca&lt;sup&gt;2+&lt;/sup&gt;/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca&lt;sup&gt;2+&lt;/sup&gt;-Activated Cl&lt;sup&gt;−&lt;/sup&gt; Channel Regulation in Cerebrovascular Cells","year":2017,"lang":"en","type":"article","venue":"Circulation Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Phosphorylation; Chemistry; Gene isoform; Angiotensin II; Gene knockdown; Molecular biology; Serine; Cell biology; Chloride channel; Protein kinase A; Biochemistry; Biology; Receptor; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","scholarly_communication","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.003705628,0.002151245,0.001931427,0.00137169,0.003507572,0.001210296,0.001585155,0.002541917,0.001765568],"category_scores_gemma":[0.001056638,0.002324157,0.001636174,0.001008088,0.0004997462,0.0008945907,0.000693838,0.001380933,0.0002991909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001686824,"about_ca_system_score_gemma":0.0009875468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001388037,"about_ca_topic_score_gemma":0.0002587412,"domain_scores_codex":[0.9864424,0.001086736,0.003818271,0.003193808,0.002982008,0.002476727],"domain_scores_gemma":[0.9893568,0.0001296369,0.003294219,0.003027403,0.002844885,0.001347051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002282607,0.001014541,0.000917878,0.0003633283,0.000835436,0.00007931962,0.001677674,0.1734264,0.8059451,0.0003965084,0.007080796,0.005980392],"study_design_scores_gemma":[0.02239458,0.001979915,0.0244372,0.0011078,0.0008626084,0.0008797373,0.0007267106,0.4284373,0.4324645,0.002673128,0.07916918,0.004867407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9344344,0.001472302,0.05144699,0.002103445,0.002856006,0.005609444,0.0005888797,0.000283883,0.001204656],"genre_scores_gemma":[0.9803122,0.0006142851,0.001455044,0.0004275955,0.004576745,0.000650041,0.003896752,0.000501289,0.007566045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3734807,"threshold_uncertainty_score":0.9998266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796533659425224,"score_gpt":0.2437262481956763,"score_spread":0.2257609116014241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}