{"id":"W2766146767","doi":"10.1177/0968533217736561","title":"The challenge of human challenge research models: A Canadian perspective","year":2017,"lang":"en","type":"article","venue":"Medical Law International","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Harm; Research ethics; Fiduciary; Vulnerability (computing); Perspective (graphical); Informed consent; Political science; Public relations; Common Rule; Engineering ethics; Psychology; Medicine; Law; Alternative medicine; Psychiatry; Duty; Computer security","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2362938,0.001514441,0.002475759,0.00554209,0.02530904,0.02866328,0.01154098,0.02039206,0.008579785],"category_scores_gemma":[0.1711629,0.001458733,0.002000969,0.005234967,0.08079968,0.01477307,0.01665494,0.02330877,0.001024741],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1538209,"about_ca_system_score_gemma":0.4266646,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8755091,"about_ca_topic_score_gemma":0.8956247,"domain_scores_codex":[0.852719,0.08816085,0.004839909,0.009231677,0.03580507,0.009243386],"domain_scores_gemma":[0.7190187,0.1825023,0.008048949,0.01459138,0.05701455,0.01882414],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00007311539,0.00005890836,0.001273676,0.0007594925,0.00005846158,0.0003670078,0.0106096,0.000494861,0.0001784566,0.9236283,0.04506374,0.01743446],"study_design_scores_gemma":[0.0001822884,0.0001934477,0.002725405,0.005891783,0.0002057703,0.0005216521,0.0151484,0.00121882,0.0003252606,0.4096359,0.563731,0.0002203434],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.002570939,0.03407772,0.01191676,0.8606802,0.002989932,0.0007003578,0.000275814,0.00006877715,0.08671945],"genre_scores_gemma":[0.2747563,0.06784512,0.06720967,0.5415721,0.003958067,0.003012133,0.0003605104,0.0002636165,0.04102257],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8461791,"threshold_uncertainty_score":0.9814478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1869842726008829,"score_gpt":0.4812024807304544,"score_spread":0.2942182081295716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}