{"id":"W2766150382","doi":"10.1172/jci90004","title":"Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Diabetes Canada","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Michigan; University of Miami; U.S. Department of Veterans Affairs","keywords":"mTORC1; Glucagon; Regulator; Biology; Secretion; Endocrinology; Internal medicine; Glucose homeostasis; Signal transduction; Cell biology; Alpha cell; PI3K/AKT/mTOR pathway; Insulin; Insulin resistance; Beta cell; Islet; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082386,0.0005517277,0.000455629,0.0005534772,0.0001424774,0.0004239054,0.0002945387,0.0004751851,0.00178068],"category_scores_gemma":[0.0001819697,0.0002805649,0.0003349897,0.0002374308,0.0005103598,0.0003414628,0.0002401631,0.0009808644,0.0004017119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497739,"about_ca_system_score_gemma":0.0002411484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002465002,"about_ca_topic_score_gemma":0.0002415338,"domain_scores_codex":[0.9997473,0.0000416426,0.00004761362,0.00005637577,0.00005164,0.00005532966],"domain_scores_gemma":[0.9997837,0.00003199891,0.00007816103,0.00002145423,0.00001005688,0.00007471355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008278187,0.00007512004,0.0002938649,0.0000402339,0.00001299971,0.0001007783,0.00001239992,0.00007282245,0.9967852,0.000107448,0.00005433922,0.001617008],"study_design_scores_gemma":[0.0001184727,0.001729758,0.01343936,0.00001776264,0.00007397443,0.001028341,0.00008683421,0.001087933,0.9793463,0.0001722082,0.002885124,0.00001401154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962491,0.001178588,0.001067168,0.0001130689,0.00004636581,0.0000180154,0.0004760479,0.0001201502,0.0007315893],"genre_scores_gemma":[0.99492,0.001126752,0.00142897,0.0001069156,0.000020193,0.00004527845,0.0005451994,0.00005703522,0.001749707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00178068,"threshold_uncertainty_score":0.005957007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06490688597260487,"score_gpt":0.3536907832029828,"score_spread":0.2887838972303779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}