{"id":"W2766151699","doi":"10.1016/j.imbio.2017.10.030","title":"Titanium dioxide nanoparticles induce human eosinophil adhesion onto endothelial EA.hy926 cells via activation of phosphoinositide 3-kinase/Akt cell signalling pathway","year":2017,"lang":"en","type":"article","venue":"Immunobiology","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail","keywords":"Protein kinase B; Wortmannin; PI3K/AKT/mTOR pathway; Cell biology; Chemistry; Adhesion; Cell adhesion; Eosinophil; MAPK/ERK pathway; Inflammation; Signal transduction; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010617,0.0002949554,0.0001397882,0.0001381248,0.0001200118,0.000258206,0.0001601097,0.0003079203,0.001395613],"category_scores_gemma":[0.00007042573,0.000140136,0.0003309633,0.00008812761,0.00008576176,0.0001395288,0.0001838137,0.000369282,0.0003339059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001655377,"about_ca_system_score_gemma":0.0001132183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005664617,"about_ca_topic_score_gemma":0.0009091187,"domain_scores_codex":[0.999879,0.0000168916,0.000009037042,0.00001907447,0.00003062397,0.00004528154],"domain_scores_gemma":[0.9999698,0.000007593954,0.000007157902,0.000004008558,0.000005631772,0.000005813742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009158681,0.00002627692,0.00006199142,0.00002571921,0.000006132921,0.00005951727,0.000009145576,0.0000243936,0.9988309,0.00006620903,0.00006370358,0.0007344298],"study_design_scores_gemma":[0.00002284444,0.0002229479,0.001842823,0.000005073905,0.00002445294,0.0001201041,0.00002845822,0.0006451163,0.995222,0.00002923316,0.001833537,0.000003434719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907809,0.001856158,0.003118662,0.0001545068,0.0001058761,0.00003169677,0.0001315349,0.0000638979,0.003756823],"genre_scores_gemma":[0.9919153,0.0007935302,0.001196057,0.00009661794,0.00001923601,0.00003341757,0.0002060426,0.00001128498,0.005728364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001395613,"threshold_uncertainty_score":0.004668772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028173210871057,"score_gpt":0.2499133739445065,"score_spread":0.229631641835796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}