{"id":"W2766223211","doi":"10.1016/j.jalz.2017.06.659","title":"[P2–011]: INCREASED PRO‐INFLAMMATORY SIGNALING AND EVIDENCE OF ALZHEIMER's DISEASE PATHOLOGY IN HEALTHY OLDER ADULTS AT RISK FOR AD","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alzheimer Society of Canada; Douglas Mental Health University Institute; McGill University","funders":"","keywords":"Medicine; Biomarker; Inflammation; Internal medicine; Placebo; Disease; Surrogate endpoint; Cognitive impairment; Oncology; Pathology; Gastroenterology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00093869,0.0007313034,0.000664574,0.0003792517,0.00113544,0.000616869,0.0005782141,0.00141358,0.01542545],"category_scores_gemma":[0.001096543,0.000329326,0.0004958849,0.0005137995,0.0004899825,0.0005746114,0.00047572,0.001284075,0.002831082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133917,"about_ca_system_score_gemma":0.0003828012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002701667,"about_ca_topic_score_gemma":0.002873681,"domain_scores_codex":[0.9995047,0.0001202554,0.00005619281,0.000182163,0.00006792331,0.00006868065],"domain_scores_gemma":[0.9994438,0.00004877351,0.000115884,0.00005148563,0.0001057508,0.0002341736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1897048,0.02016728,0.4156746,0.001223673,0.001312618,0.0145512,0.001750643,0.0003135981,0.1814816,0.003068378,0.04329566,0.1274561],"study_design_scores_gemma":[0.006335332,0.0370901,0.8834645,0.0002474561,0.0008061326,0.01508829,0.0007182401,0.0006312514,0.006506959,0.002741488,0.0462313,0.0001388358],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760444,0.0009381264,0.00108522,0.001490121,0.0006019614,0.0003210484,0.003263086,0.00006841625,0.01618754],"genre_scores_gemma":[0.9750012,0.0005113263,0.001806452,0.002933908,0.0004473415,0.00040082,0.003239932,0.0001049036,0.01555405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01542545,"threshold_uncertainty_score":0.05160326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04069112790730997,"score_gpt":0.3392081816778962,"score_spread":0.2985170537705862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}