{"id":"W2766229554","doi":"10.1021/acsinfecdis.7b00138","title":"Daptomycin Pore Formation Is Restricted by Lipid Acyl Chain Composition","year":2017,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Daptomycin; Phosphatidylglycerol; Membrane; Lipopeptide; Phosphatidylcholine; Phospholipid; Chemistry; Biochemistry; Cell membrane; Calcium; Biophysics; Biology; Bacteria; Vancomycin; Staphylococcus aureus; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002805589,0.0001598186,0.0001228506,0.00003643049,0.0004533445,0.0001254724,0.000203746,0.0001315365,0.00003258147],"category_scores_gemma":[0.00006126517,0.0001489144,0.00008626469,0.000037086,0.0000771074,0.00002918854,0.00009522324,0.00007129563,0.00001376625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002041336,"about_ca_system_score_gemma":0.00003725386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005908247,"about_ca_topic_score_gemma":0.00001612138,"domain_scores_codex":[0.9992391,0.00003291979,0.0001563289,0.0002510624,0.000126681,0.000193944],"domain_scores_gemma":[0.9990764,0.000006092604,0.0001720538,0.0005519893,0.00008723873,0.000106282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005594065,0.0001252421,0.03062675,0.00002804231,0.00003483958,0.000003690793,0.00002840317,0.0000025581,0.9363019,0.00002460529,0.02805829,0.004709678],"study_design_scores_gemma":[0.001131752,0.0002472716,0.05767416,0.00002030271,0.0001224464,0.00003804873,0.00001799757,0.00001284655,0.9121885,0.00005944992,0.02819136,0.0002958529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972943,0.0001189709,0.0001554908,0.0002193646,0.000323044,0.0002175014,0.0003101487,0.00005007441,0.001311126],"genre_scores_gemma":[0.9964786,0.0001825932,0.00001171174,0.0005218724,0.0005506398,0.0000339521,0.001897705,0.00001897329,0.0003039112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02704741,"threshold_uncertainty_score":0.6072552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007139872034019504,"score_gpt":0.2561943872414012,"score_spread":0.2490545152073817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}