{"id":"W2766236308","doi":"10.1371/journal.pone.0187584","title":"Non-radioactive 2-deoxy-2-fluoro-D-glucose inhibits glucose uptake in xenograft tumours and sensitizes HeLa cells to doxorubicin in vitro","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thunder Bay Regional Research Institute; University of Saskatchewan; NOSM University; Lakehead University","funders":"Northern Ontario Academic Medicine Association","keywords":"HeLa; Doxorubicin; Glucose uptake; Apoptosis; Glycolysis; Hexokinase; In vivo; Cytotoxicity; Cancer cell; Hypoxia (environmental); 2-Deoxy-D-glucose; Cancer research; In vitro; Chemistry; Glucose transporter; Pharmacology; Biochemistry; Biology; Medicine; Cancer; Chemotherapy; Metabolism; Internal medicine; Oxygen; Endocrinology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001667065,0.0004924616,0.0003739797,0.0002673331,0.0001339274,0.0002178377,0.0002604421,0.0002735691,0.001277684],"category_scores_gemma":[0.0001006519,0.0002047451,0.0002829959,0.0001594386,0.0001590747,0.0002080534,0.000131962,0.0004524683,0.0003256283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003616636,"about_ca_system_score_gemma":0.000216854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002137066,"about_ca_topic_score_gemma":0.003994239,"domain_scores_codex":[0.999867,0.0000292464,0.00001137854,0.00003576038,0.00002390457,0.00003274211],"domain_scores_gemma":[0.9999214,0.00002243683,0.00001554983,0.00001577547,0.000008087432,0.00001673773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008465092,0.00003364327,0.0001065547,0.00003349524,0.000005304227,0.00002554736,0.00001598898,0.00008839999,0.9988834,0.00003967528,0.00004962882,0.000633587],"study_design_scores_gemma":[0.00001210227,0.0004110734,0.001736849,0.000006080823,0.00001283653,0.00008414379,0.00001353439,0.0007756085,0.9952456,0.00001205869,0.001687076,0.00000301327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789382,0.007946678,0.007764174,0.0001789928,0.0001230149,0.0001009843,0.0009771808,0.0002230196,0.003747766],"genre_scores_gemma":[0.9775642,0.005276538,0.009347265,0.00008024575,0.00002820942,0.0001165385,0.001498116,0.0001004915,0.005988399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002137066,"threshold_uncertainty_score":0.004274309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636728201643302,"score_gpt":0.2338348535429917,"score_spread":0.2174675715265587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}