{"id":"W2766237975","doi":"10.1111/tpj.13760","title":"Discovery of a non‐stereoselective cytochrome P450 catalyzing either 8α‐ or 8β‐hydroxylation of germacrene A acid from the Chinese medicinal plant, <i>Inula hupehensis</i>","year":2017,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Sesquiterpenes and Asteraceae Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Rural Development Administration; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Ministry of Education","keywords":"Hydroxylation; Stereoselectivity; Stereochemistry; Moiety; Cytochrome P450; Sesquiterpene; Lactone; Biology; Polyketide; Biosynthesis; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008299371,0.000248629,0.0001381477,0.0001695609,0.0001452914,0.0001965075,0.000130405,0.0002430778,0.0004850425],"category_scores_gemma":[0.00008540944,0.00009322111,0.0002444166,0.0001262518,0.0001066668,0.0001580496,0.0001540868,0.00028503,0.000302948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001548226,"about_ca_system_score_gemma":0.0002078143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006520725,"about_ca_topic_score_gemma":0.0005408476,"domain_scores_codex":[0.9999516,0.000005518126,0.000003564775,0.00001362029,0.00001395138,0.00001175466],"domain_scores_gemma":[0.9999489,0.000005843904,0.00001849149,0.000006556269,0.00000954493,0.00001070239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003671231,0.00001953238,0.0008472661,0.00004605559,0.000006791593,0.0001529134,0.00001122198,0.00003676283,0.9939247,0.0001376804,0.00007018453,0.004710265],"study_design_scores_gemma":[0.00001432259,0.0002106802,0.01403967,0.000004781531,0.00003567275,0.001103,0.00002954773,0.0005533004,0.9759483,0.0001174314,0.007935931,0.000007250248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812744,0.003112934,0.01020226,0.0004986212,0.000052649,0.00007839966,0.0009454374,0.0001718131,0.003663472],"genre_scores_gemma":[0.9837614,0.002074124,0.007129895,0.0001728616,0.00003888909,0.00002486339,0.002455682,0.00001631833,0.004326038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006520725,"threshold_uncertainty_score":0.001622617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01474990220774013,"score_gpt":0.2742750608084906,"score_spread":0.2595251586007505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}