{"id":"W2766243414","doi":"10.1007/s13318-017-0440-z","title":"Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study","year":2017,"lang":"en","type":"article","venue":"European Journal of Drug Metabolism and Pharmacokinetics","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Pharmacokinetics; Tolerability; Pharmacology; NMDA receptor; Placebo; Adverse effect; Medicine; Bioavailability; Oral administration; Internal medicine; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003210069,0.0004310372,0.001255324,0.000234418,0.0001727383,0.00008595143,0.0005085986,0.00006901874,0.00004403116],"category_scores_gemma":[0.0001518471,0.0003646321,0.00022536,0.0001047205,0.0003012303,0.00004915885,0.0001989119,0.0004589733,6.841747e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001208234,"about_ca_system_score_gemma":0.0000749556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006719729,"about_ca_topic_score_gemma":0.0002268791,"domain_scores_codex":[0.9960884,0.0008403239,0.001806978,0.0004628817,0.0003544856,0.0004468974],"domain_scores_gemma":[0.99796,0.00005324356,0.0009779275,0.0004524271,0.0002323704,0.0003239829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3542896,0.006431806,0.1071884,0.0005528483,0.001221863,0.0009270715,0.008352061,0.002140307,0.4812967,0.00003934067,0.001560468,0.03599958],"study_design_scores_gemma":[0.7184865,0.003050186,0.1568253,0.0002386235,0.001679419,0.0001983197,0.0009186256,0.0005755968,0.03731825,0.00002678174,0.07962303,0.001059381],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876754,0.00939802,0.0002026764,0.0004748641,0.00069969,0.001059357,0.00004764228,0.000004405949,0.0004379652],"genre_scores_gemma":[0.9924273,0.005968914,0.0004628612,0.0001816771,0.0007402821,0.000009795205,0.0000107051,0.00005702006,0.0001414342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4439784,"threshold_uncertainty_score":0.9998806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881510331966059,"score_gpt":0.2862118875924309,"score_spread":0.2673967842727703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}