{"id":"W2766243414","doi":"10.1007/s13318-017-0440-z","title":"Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study","year":2017,"lang":"en","type":"article","venue":"European Journal of Drug Metabolism and Pharmacokinetics","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Pharmacokinetics; Tolerability; Pharmacology; NMDA receptor; Placebo; Adverse effect; Medicine; Bioavailability; Oral administration; Internal medicine; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001958593,0.001526183,0.00281844,0.0004661542,0.0005133449,0.0008353927,0.0006347534,0.001431752,0.004498694],"category_scores_gemma":[0.001513366,0.001024019,0.001109441,0.0004714482,0.001167005,0.0008897391,0.000361008,0.001463922,0.001405883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004862718,"about_ca_system_score_gemma":0.0008569824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000853051,"about_ca_topic_score_gemma":0.001152434,"domain_scores_codex":[0.9990504,0.0004779393,0.00007316502,0.0001726444,0.0001102165,0.0001156613],"domain_scores_gemma":[0.9991505,0.0001593457,0.0002177821,0.00009948374,0.0000927317,0.0002801363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9122888,0.02340784,0.001932413,0.0005655466,0.0007543233,0.0001210937,0.0001727252,0.0002889016,0.04018321,0.00004664467,0.0005514159,0.01968707],"study_design_scores_gemma":[0.2879644,0.6839619,0.01971256,0.0000261749,0.001119724,0.0001694371,0.0000803033,0.0006802392,0.004836719,0.00008853224,0.001306319,0.00005367929],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948154,0.001221297,0.000610401,0.0000848647,0.00006864778,0.001777262,0.0006257409,0.00007944053,0.0007169073],"genre_scores_gemma":[0.9917891,0.001382554,0.001143588,0.0003827651,0.0001974508,0.001871602,0.0007707801,0.00003700704,0.002425106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004498694,"threshold_uncertainty_score":0.01504964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881510331966059,"score_gpt":0.2862118875924309,"score_spread":0.2673967842727703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}