{"id":"W2766243515","doi":"10.1038/onc.2017.385","title":"Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer","year":2017,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Prostate Cancer Canada; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation; U.S. Department of Defense","keywords":"Prostate cancer; Biology; Androgen receptor; Cancer research; Androgen; Carcinogenesis; Gene silencing; Cancer; Endocrinology; Internal medicine; Biochemistry; Hormone; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181544,0.0001142498,0.0001733428,0.00002519861,0.0001659307,0.00001925066,0.0002160341,0.00009766444,0.00002294054],"category_scores_gemma":[0.00009679206,0.00007988495,0.00008235937,0.00004608939,0.000195305,0.0000096742,0.00006184806,0.00003799803,7.574371e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009558143,"about_ca_system_score_gemma":0.0001958861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000277587,"about_ca_topic_score_gemma":0.0002019471,"domain_scores_codex":[0.9992114,0.00004893471,0.0002445217,0.0002109846,0.000151041,0.0001331505],"domain_scores_gemma":[0.9987882,0.00001000328,0.0004743413,0.0004987585,0.000190357,0.0000383842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000297497,0.00004894713,0.001463899,0.00002734666,0.00007131649,2.346756e-8,0.0001340484,0.00001249466,0.9442873,0.00002927266,0.001995302,0.05163254],"study_design_scores_gemma":[0.0003387946,0.0001023842,0.006716116,0.00006176899,0.00003660058,9.127494e-7,0.00005635262,0.000007330407,0.833324,0.000009174059,0.1592647,0.00008189168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995598,0.001822668,0.00001434932,0.0004192482,0.001217799,0.0003052545,0.0001209198,0.000005101585,0.0004966737],"genre_scores_gemma":[0.9951359,0.001911781,0.0003173303,0.0000150751,0.001955714,0.00004719213,0.00006161326,0.00001655385,0.0005388106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1572694,"threshold_uncertainty_score":0.3257614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337499561741102,"score_gpt":0.2891168595435497,"score_spread":0.2757418639261386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}