{"id":"W2766247145","doi":"10.1373/clinchem.2017.280172","title":"Partitioning the Genetic Architecture of Plasma Lipoprotein(a) and Kringle IV Type 2 Repeats: Implications for Therapeutic Lowering","year":2017,"lang":"en","type":"letter","venue":"Clinical Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Heart and Stroke Foundation; University of Toronto","funders":"Peter Munk Cardiac Centre, University Health Network; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Plasma lipoprotein; Lipoprotein(a); Lipoprotein; Plasma concentration; Genetics; Chemistry; Pharmacology; Biology; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001659078,0.0004457388,0.0008881591,0.0005488924,0.0002726629,0.001418605,0.0009867201,0.00148044,0.002195133],"category_scores_gemma":[0.004115482,0.0002441895,0.0003153245,0.0005465918,0.0009801987,0.0008983403,0.0004087396,0.001259613,0.0003750431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008229967,"about_ca_system_score_gemma":0.0009496419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00160513,"about_ca_topic_score_gemma":0.001591665,"domain_scores_codex":[0.9994538,0.0002647701,0.000026073,0.0001057604,0.0001056198,0.0000439733],"domain_scores_gemma":[0.9985299,0.0007687145,0.0003630355,0.00006566271,0.0001459628,0.0001267105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005862223,0.001803267,0.2089617,0.00184655,0.001005869,0.001822801,0.0009353549,0.01610099,0.0648791,0.05109147,0.0162997,0.629391],"study_design_scores_gemma":[0.001201124,0.007510726,0.500039,0.002191788,0.002261467,0.006987993,0.003923479,0.0788824,0.01380357,0.2832566,0.099482,0.0004598879],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.596536,0.2572947,0.04860259,0.07896208,0.001161707,0.0002150886,0.0008523849,0.0002442294,0.01613123],"genre_scores_gemma":[0.929985,0.0468617,0.01560641,0.004983312,0.001083001,0.000103061,0.0002635896,0.00004742465,0.00106655],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002195133,"threshold_uncertainty_score":0.008774161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06156990422041187,"score_gpt":0.3554176616345613,"score_spread":0.2938477574141495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}