{"id":"W2766278911","doi":"10.1038/s41598-017-12777-7","title":"Phosphorylable tyrosine residue 162 in the double-stranded RNA-dependent kinase PKR modulates its interaction with SUMO","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs","funders":"Instituto de Salud Carlos III; Ministerio de Economía y Competitividad; Consejo Nacional de Ciencia y Tecnología","keywords":"Protein kinase R; Phosphorylation; EIF-2 kinase; Cell biology; Biology; Tyrosine; SUMO protein; Protein kinase A; RNA; Pact; RNA silencing; Chemistry; Biochemistry; RNA interference; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; Ubiquitin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001321371,0.0002459093,0.0001701733,0.00006396191,0.0001088765,0.0001872974,0.0001080139,0.0001700799,0.001560333],"category_scores_gemma":[0.0001138249,0.00008274061,0.0001555107,0.0000661771,0.0001866205,0.0002172248,0.0001782307,0.0002940421,0.000496592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001584284,"about_ca_system_score_gemma":0.0001033512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009045877,"about_ca_topic_score_gemma":0.0001305109,"domain_scores_codex":[0.9999393,0.00001387352,0.000004347694,0.00001527487,0.0000116044,0.00001568497],"domain_scores_gemma":[0.9999517,0.000006082456,0.00002133945,0.000004881857,0.000003631692,0.00001238297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001718618,0.00001596757,0.0004014201,0.00002169977,0.000004192966,0.00007428532,0.000008704048,0.00006231342,0.9983846,0.00007934818,0.00001596778,0.0007597039],"study_design_scores_gemma":[0.00003071152,0.0002666853,0.007492896,0.000004521081,0.00001032,0.0003956143,0.00003087419,0.000954525,0.9898301,0.00009221048,0.0008866341,0.000005048529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977182,0.0006288387,0.0008463668,0.00004889721,0.00001495883,0.000005306144,0.00003785019,0.0000100931,0.0006895236],"genre_scores_gemma":[0.9979215,0.0003826383,0.0004876366,0.00001854765,0.000006676717,0.000005248362,0.00007026377,0.000005029071,0.001102439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001560333,"threshold_uncertainty_score":0.005219817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248072636407388,"score_gpt":0.2740908902690942,"score_spread":0.2492836266283554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}