{"id":"W2766291043","doi":"10.1111/jdv.14647","title":"Apremilast for the treatment of moderate‐to‐severe palmoplantar psoriasis: results from a double‐blind, placebo‐controlled, randomized study","year":2017,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexus Clinical Research (Canada); SKiN Health; Merck Canada Inc. (Canada); Lynde Centre for Dermatology; Recyc PHP (Canada); Innovation Initiatives Ontario North; Manitoba Beekeepers' Association; Centre de Recherche Dermatologique du Québec Métropolitain; Innovaderm (Canada)","funders":"Novo Nordisk; Valeant Pharmaceuticals International; Regeneron Pharmaceuticals; Celgene; Novartis; AbbVie; Sanofi; Merck; GlaxoSmithKline; LEO Pharma Research Foundation; Pfizer; Boehringer Ingelheim; Amgen; Eli Lilly and Company; DUSA Pharmaceuticals; Abbott Fund","keywords":"Medicine; Apremilast; Psoriasis; Dermatology; Placebo; Randomized controlled trial; Double blind; Palmoplantar pustulosis; Internal medicine; Alternative medicine; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001308786,0.0003126308,0.00180409,0.0001418616,0.0005961137,0.00001580106,0.000924671,0.0002709428,0.00001354881],"category_scores_gemma":[0.0004090943,0.0001528561,0.000567355,0.0000442495,0.0007069632,0.00007677362,0.0001550575,0.000272586,0.000009774431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001924719,"about_ca_system_score_gemma":0.00005617533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004930541,"about_ca_topic_score_gemma":0.0000297021,"domain_scores_codex":[0.9956093,0.002417351,0.001320987,0.0002845323,0.00006573132,0.0003021053],"domain_scores_gemma":[0.9943607,0.002791014,0.002262217,0.0004383905,0.0001009327,0.00004676678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.966385,0.0007698698,0.01246799,0.00001380093,0.007862327,0.00003736559,0.003587478,0.0001256251,0.002056638,0.0002978478,0.001100069,0.005295995],"study_design_scores_gemma":[0.9553325,0.0004659418,0.01548694,0.00008641171,0.004875888,0.001373249,0.0006308872,0.00003313308,0.01621122,0.0006227132,0.004660099,0.0002210069],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846871,0.006793302,0.00007386041,0.004738072,0.001231048,0.001776864,0.0001430755,0.000007080319,0.0005496367],"genre_scores_gemma":[0.9972647,0.001754954,0.0001057002,0.0001015377,0.0001932862,0.00005230048,0.00000756068,0.00002112734,0.0004988269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01415459,"threshold_uncertainty_score":0.6233289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0427613775513459,"score_gpt":0.2904193061054218,"score_spread":0.2476579285540759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}