{"id":"W2766361906","doi":"10.1128/jvi.01409-17","title":"Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals","year":2017,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Cancer Institute; National Institute of Mental Health; Howard Hughes Medical Institute; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Japan Agency for Medical Research and Development","keywords":"Biology; Major histocompatibility complex; CD8; MHC class I; Downregulation and upregulation; Virology; T cell; Human leukocyte antigen; Cytotoxic T cell; Immune system; Genetics; Immunology; Antigen; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138814,0.0001049103,0.0001309118,0.0001092393,0.0001289477,0.0001956393,0.00006140611,0.0001576246,0.0009362993],"category_scores_gemma":[0.0002357015,0.00006330612,0.00008619655,0.00006038075,0.00007798168,0.00006569246,0.00005209678,0.0001853492,0.0001423368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009103701,"about_ca_system_score_gemma":0.0000502717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003256997,"about_ca_topic_score_gemma":0.0003345732,"domain_scores_codex":[0.9999322,0.00001590888,0.000006141996,0.00001736319,0.00001260716,0.00001566107],"domain_scores_gemma":[0.9999189,0.00002426685,0.00001807631,0.000008140371,0.000007918707,0.00002264449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003386955,0.00005353531,0.02961201,0.00001512523,0.00002059271,0.0001797959,0.00006811151,0.0001024957,0.9645819,0.00007940533,0.00004949503,0.004898889],"study_design_scores_gemma":[0.00006814962,0.002971503,0.5642523,0.00002298281,0.00009188664,0.00979598,0.0003253528,0.002613452,0.4157879,0.0002012931,0.003853894,0.00001536388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995564,0.0001053909,0.0001014244,0.00000446723,0.000001095819,0.000002543426,0.00001775089,0.000002407891,0.0002085323],"genre_scores_gemma":[0.9996049,0.00005217331,0.00012034,0.000009080891,0.000001554979,0.000002723197,0.00003615832,0.000002154616,0.0001709674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009362993,"threshold_uncertainty_score":0.003132224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04104407127282983,"score_gpt":0.3207960379191048,"score_spread":0.279751966646275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}