{"id":"W2766363568","doi":"10.1080/15592294.2017.1380760","title":"Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity","year":2017,"lang":"en","type":"article","venue":"Epigenetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; University of Alberta; University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"Trichostatin A; MECP2; Chromatin; Acetylation; Biology; Histone; Histone deacetylase; Histone deacetylase inhibitor; Epigenetics; Cell biology; Phosphorylation; Molecular biology; Genetics; DNA; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006555284,0.0002789161,0.0002362049,0.0001908657,0.0001130915,0.0001986947,0.0001311249,0.0001799184,0.001832018],"category_scores_gemma":[0.00011818,0.00009184523,0.0002721777,0.0001610413,0.0002130545,0.0001221688,0.0001346986,0.0004323511,0.0002723394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392978,"about_ca_system_score_gemma":0.0002256135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143592,"about_ca_topic_score_gemma":0.001907501,"domain_scores_codex":[0.9999002,0.00001461746,0.00001057515,0.00001462798,0.00003046567,0.00002945529],"domain_scores_gemma":[0.9998984,0.00002176675,0.00003082588,0.00001085947,0.00000980905,0.00002830484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007361989,0.00001135426,0.0001886234,0.00001799454,0.00000606964,0.00003294486,0.000004504323,0.00001185624,0.9990045,0.00001850014,0.00003089068,0.0005991186],"study_design_scores_gemma":[0.000006970692,0.000194596,0.007709105,0.000002214549,0.00001245902,0.0002429833,0.00002499977,0.0001130973,0.9902654,0.0000141497,0.00141176,0.000002152926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936934,0.002256554,0.00131702,0.0001630135,0.0000495339,0.00001396997,0.0006009537,0.00006625587,0.001839362],"genre_scores_gemma":[0.993461,0.001805958,0.001584204,0.00008864687,0.00001657167,0.00002401604,0.0007802863,0.00001888485,0.002220498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001832018,"threshold_uncertainty_score":0.006128669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02386726782323802,"score_gpt":0.2678879529136326,"score_spread":0.2440206850903946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}