{"id":"W2766401179","doi":"10.3390/cancers9110151","title":"Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer","year":2017,"lang":"en","type":"review","venue":"Cancers","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"U.S. Bureau of Land Management","keywords":"Cancer; Chromosome instability; Disease; Medicine; Bioinformatics; Exploit; Etiology; Drug development; Oncology; Internal medicine; Chromosome; Drug; Biology; Gene; Genetics; Computer science; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001481049,0.0003668203,0.000808958,0.00008365634,0.00008002655,0.00009414462,0.0005942897,0.0003692214,0.000058242],"category_scores_gemma":[0.00003322727,0.000333911,0.0002546803,0.00009937634,0.00008409991,0.000009095061,0.0001654938,0.0002332589,0.0000133021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009950666,"about_ca_system_score_gemma":0.003358772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008068685,"about_ca_topic_score_gemma":0.004250349,"domain_scores_codex":[0.9984714,0.00007160476,0.0003532562,0.0006338229,0.0000943663,0.0003755231],"domain_scores_gemma":[0.9987836,0.000009963817,0.0002009415,0.0008527421,0.00005479301,0.00009794871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001076407,0.00001317061,0.00005140804,0.00371999,0.000156968,0.000004743332,0.00009617834,0.0001017156,0.0009833645,0.00002180387,0.0005873512,0.9942526],"study_design_scores_gemma":[0.0001192772,0.00006191276,0.00002419094,0.002527895,0.00009294144,0.000003065946,0.000060981,0.000005729536,0.0000875089,0.00001274418,0.9966054,0.0003983524],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001378443,0.9962459,0.00007766497,0.00001237674,0.0004812395,0.000709547,0.0001186848,0.00001020881,0.0009659622],"genre_scores_gemma":[0.003894609,0.9944398,0.0000399483,0.0001103505,0.000340516,0.0006389191,0.0001113413,0.00005843973,0.0003661237],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9960181,"threshold_uncertainty_score":0.9999113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0751943634481782,"score_gpt":0.3746443718296898,"score_spread":0.2994500083815116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}