{"id":"W2766409016","doi":"10.1016/j.celrep.2017.09.081","title":"Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":390,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Australian Centre for HIV and Hepatitis Virology Research; amfAR, The Foundation for AIDS Research","keywords":"Biology; Genome; Effector; Genetics; Replication (statistics); Viral replication; Virology; Virus latency; Lentivirus; Human immunodeficiency virus (HIV); Computational biology; Virus; Gene; Viral disease; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002794368,0.0001346472,0.0002741962,0.00008034152,0.0001303925,0.00003619014,0.0001597915,0.0001352506,0.0002797655],"category_scores_gemma":[0.0001272812,0.0001126183,0.00006627181,0.00004092214,0.0002252365,0.00007816945,0.00007551521,0.0001335607,0.0009120573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000555542,"about_ca_system_score_gemma":0.00007071115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006456025,"about_ca_topic_score_gemma":0.00008427438,"domain_scores_codex":[0.9985788,0.0001506164,0.0004941032,0.0003879898,0.00005740989,0.0003310833],"domain_scores_gemma":[0.998611,0.0001077603,0.0004015065,0.0007743631,0.000062761,0.00004266156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001083966,0.0004017131,0.2016133,0.00001146807,0.00005520693,0.0003352931,0.0001395933,0.000002651263,0.7938616,0.000002852776,0.0004675646,0.003000366],"study_design_scores_gemma":[0.0004696709,0.00007101983,0.4064262,0.0000164459,0.00001750675,0.000005147697,0.00001367154,0.00000100263,0.5917439,0.00004695149,0.001130657,0.00005774212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965101,0.0007802728,0.0000295153,0.00001926364,0.0002387736,0.0004812283,0.00007736649,0.00001805261,0.001845428],"genre_scores_gemma":[0.9979153,0.0001389204,0.00002679946,0.000002812823,0.00001360032,0.00006167043,0.0001471418,0.00001266248,0.001681094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2048129,"threshold_uncertainty_score":0.9998658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02921280331246488,"score_gpt":0.2860198404964453,"score_spread":0.2568070371839804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}