{"id":"W2766452915","doi":"10.1503/cmaj.170195","title":"We need a “made in Canada” orphan drug framework","year":2017,"lang":"en","type":"article","venue":"Canadian Medical Association Journal","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Children's Hospital of Eastern Ontario; Children’s Health Research Institute; University of Ottawa; Western University","funders":"","keywords":"Orphan drug; Limiting; Medicine; Drug; Key (lock); Family medicine; Pharmacology; Bioinformatics; Computer science; Biology; Computer security; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02401645,0.001176724,0.001762715,0.002304703,0.01145734,0.01698713,0.006856712,0.02042903,0.05337521],"category_scores_gemma":[0.04995067,0.0009485233,0.002092108,0.002375124,0.009780472,0.009777928,0.008657804,0.02537343,0.009155371],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0559455,"about_ca_system_score_gemma":0.4326796,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8506316,"about_ca_topic_score_gemma":0.906057,"domain_scores_codex":[0.9709004,0.003931683,0.001229162,0.001986107,0.01496892,0.006983811],"domain_scores_gemma":[0.884693,0.009287476,0.002410414,0.002706682,0.05495664,0.04594579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005428982,0.00006894313,0.0007573062,0.0002770581,0.00003077446,0.0003882645,0.0002311113,0.0002711146,0.0002885125,0.08166129,0.8887731,0.02719822],"study_design_scores_gemma":[0.00003778741,0.00003512272,0.0008974618,0.0007687071,0.00002350058,0.0001439655,0.000381764,0.0001612779,0.0001330613,0.008639601,0.9887062,0.0000715557],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0005823142,0.005512438,0.001918268,0.9275011,0.01128044,0.0001952676,0.001175238,0.0003400717,0.05149494],"genre_scores_gemma":[0.01957568,0.01161843,0.01926869,0.8706891,0.004698284,0.0002818367,0.00175073,0.0003741165,0.07174327],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9440545,"threshold_uncertainty_score":0.4059149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.010657770337196,"score_gpt":0.275400096967315,"score_spread":0.264742326630119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}