{"id":"W2766489743","doi":"10.1371/journal.pgen.1006864","title":"Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder","year":2017,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"National Institutes of Health; ZonMw; Canada Research Chairs; Children's Health Research Institute","keywords":"Biology; Genetics; Haploinsufficiency; Histone methyltransferase; Drosophila melanogaster; Gene knockdown; Histone; Methyltransferase; Epigenetics; Gene; Phenotype; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008867715,0.0001242071,0.0001569104,0.00002682485,0.00008917381,0.00001531403,0.00009518456,0.000130223,0.00004690725],"category_scores_gemma":[0.0001554324,0.0001314455,0.00003193505,0.00003532561,0.000569284,0.000005443676,0.0001005117,0.00007284073,8.717848e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002247102,"about_ca_system_score_gemma":0.00004825696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008849516,"about_ca_topic_score_gemma":0.001370906,"domain_scores_codex":[0.9991907,0.00004046936,0.0002104051,0.0003104722,0.0001089465,0.0001389805],"domain_scores_gemma":[0.9994656,0.00003341067,0.00007276559,0.0003489869,0.0000245719,0.00005459922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002047681,0.000172414,0.2250593,0.00008378465,0.00007734109,5.352554e-7,0.0002580747,0.0002659386,0.7707216,0.00008665634,0.00009548236,0.002974144],"study_design_scores_gemma":[0.0008397767,0.0002579597,0.3664041,0.00002370129,0.00004586562,0.000003875332,0.00005924735,0.00269105,0.6282954,0.0006276886,0.0005485339,0.0002028636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942214,0.004273045,0.0006190523,0.0005185537,0.0001232016,0.0001798348,0.00002413477,0.000004503165,0.00003625005],"genre_scores_gemma":[0.9976469,0.001976348,0.0001703811,0.00001409722,0.00006519202,0.00001037159,0.00003706595,0.00001356959,0.00006602601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1424263,"threshold_uncertainty_score":0.5360194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946933619155737,"score_gpt":0.2724219339421335,"score_spread":0.2529525977505762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}