{"id":"W2766503838","doi":"10.1001/jamapsychiatry.2017.3016","title":"Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations","year":2017,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Mental Health; NHLBI Division of Intramural Research; Institute of Molecular and Cell Biology; Stanley Center for Psychiatric Research, Broad Institute; University of North Carolina at Chapel Hill; School of Medicine, Emory University; National Institutes of Health; Ministry of Cultural Affairs; H. Lundbeck A/S; Medical Research Council; Siemens Healthineers; Tartu Ülikool; Leids Universitair Medisch Centrum; Westfälische Wilhelms-Universität Münster; Dokuz Eylül Üniversitesi; Vetenskapsrådet; Novo Nordisk; University of Toronto; Nederlands Instituut voor Onderzoek van de Gezondheidszorg; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Region Hovedstaden; GGZ Drenthe; Institute of Genetics; Department of Psychiatry, University of Toronto; Universität Greifswald; GGZ Friesland; Statens Serum Institut; GGZ inGeest; Háskóli Íslands; Bundesministerium für Bildung und Forschung; Janssen Research and Development; ZonMw; Rijksuniversiteit Groningen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Australian Research Council; Trinity College Dublin; Universiteit Leiden; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Glasgow; Rheinische Friedrich-Wilhelms-Universität Bonn; Universitair Medisch Centrum Groningen; Università degli Studi di Trento; Newcastle University; Vrije Universiteit Amsterdam; Stiftelsen för Strategisk Forskning; University of Oxford; National Cancer Institute; Lundbeckfonden; University College London; Albert-Ludwigs-Universität Freiburg; King's College London; Aarhus Universitet; Massachusetts Institute of Technology; Universität Basel; QIMR Berghofer Medical Research Institute; South London and Maudsley NHS Foundation Trust; Virginia Commonwealth University; James Cook University; Cardiff University; University of Texas Southwestern Medical Center; University of Southern California; Foundation for the National Institutes of Health; Broad Institute; F. Hoffmann-La Roche; Queensland University of Technology; Brigham and Women's Hospital; Kaiser Permanente; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Emory University; National Institute for Health and Care Research; Universidad de Granada; Rigshospitalet; Aarhus Universitetshospital; Dalhousie University; Universitätsmedizin Göttingen; GlaxoSmithKline; Centre for Cognitive Ageing and Cognitive Epidemiology; Washington University in St. Louis; European Commission; Wellcome Trust; National Science Foundation; Massachusetts General Hospital; Rivierduinen; Pfizer; McDonnell Center for Systems Neuroscience; University of California, San Diego; Johns Hopkins University; Chinese Society of Clinical Oncology; Amgen","keywords":"Depression (economics); Association (psychology); Obesity; Medicine; Genome-wide association study; Psychiatry; Psychology; Genetics; Biology; Internal medicine; Single-nucleotide polymorphism; Genotype; Gene; Psychotherapist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007653017,0.0001091409,0.0001490676,0.00007009469,0.0004342531,0.0001290727,0.0002421466,0.0001424015,0.00004666468],"category_scores_gemma":[0.0002520836,0.00008667607,0.00004423299,0.0001018514,0.000123947,0.0002186969,0.00006477373,0.0001743134,0.000009717013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001215176,"about_ca_system_score_gemma":0.00004122407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000217078,"about_ca_topic_score_gemma":0.0000701316,"domain_scores_codex":[0.9991114,0.0000711449,0.0001653407,0.000264016,0.0002196677,0.0001684942],"domain_scores_gemma":[0.9991448,0.00006785065,0.0003119182,0.0003928818,0.00002897453,0.00005356188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001850736,0.0001857134,0.962051,0.00003019505,0.00002516445,0.000001262266,0.0001803167,0.0000163968,0.02587307,0.004766396,0.001732832,0.004952597],"study_design_scores_gemma":[0.001719104,0.0000399384,0.9919016,0.00004244868,0.00002357411,0.00001303258,0.00003031359,0.00006006618,0.003276901,0.002530733,0.0002520045,0.0001102669],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941516,0.0006089829,0.00003690214,0.002157258,0.0003389354,0.0001704121,0.00001289788,0.00003613054,0.002486898],"genre_scores_gemma":[0.9976442,0.00005729621,0.001086612,0.0001984092,0.00006260596,0.00000643211,0.000001748271,0.00001379108,0.0009288617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02985063,"threshold_uncertainty_score":0.3534547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006178756694654128,"score_gpt":0.2343133093087598,"score_spread":0.2281345526141056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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