{"id":"W2766503838","doi":"10.1001/jamapsychiatry.2017.3016","title":"Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations","year":2017,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Mental Health; NHLBI Division of Intramural Research; Institute of Molecular and Cell Biology; Stanley Center for Psychiatric Research, Broad Institute; University of North Carolina at Chapel Hill; School of Medicine, Emory University; National Institutes of Health; Ministry of Cultural Affairs; H. Lundbeck A/S; Medical Research Council; Siemens Healthineers; Tartu Ülikool; Leids Universitair Medisch Centrum; Westfälische Wilhelms-Universität Münster; Dokuz Eylül Üniversitesi; Vetenskapsrådet; Novo Nordisk; University of Toronto; Nederlands Instituut voor Onderzoek van de Gezondheidszorg; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Region Hovedstaden; GGZ Drenthe; Institute of Genetics; Department of Psychiatry, University of Toronto; Universität Greifswald; GGZ Friesland; Statens Serum Institut; GGZ inGeest; Háskóli Íslands; Bundesministerium für Bildung und Forschung; Janssen Research and Development; ZonMw; Rijksuniversiteit Groningen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Australian Research Council; Trinity College Dublin; Universiteit Leiden; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Glasgow; Rheinische Friedrich-Wilhelms-Universität Bonn; Universitair Medisch Centrum Groningen; Università degli Studi di Trento; Newcastle University; Vrije Universiteit Amsterdam; Stiftelsen för Strategisk Forskning; University of Oxford; National Cancer Institute; Lundbeckfonden; University College London; Albert-Ludwigs-Universität Freiburg; King's College London; Aarhus Universitet; Massachusetts Institute of Technology; Universität Basel; QIMR Berghofer Medical Research Institute; South London and Maudsley NHS Foundation Trust; Virginia Commonwealth University; James Cook University; Cardiff University; University of Texas Southwestern Medical Center; University of Southern California; Foundation for the National Institutes of Health; Broad Institute; F. Hoffmann-La Roche; Queensland University of Technology; Brigham and Women's Hospital; Kaiser Permanente; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Emory University; National Institute for Health and Care Research; Universidad de Granada; Rigshospitalet; Aarhus Universitetshospital; Dalhousie University; Universitätsmedizin Göttingen; GlaxoSmithKline; Centre for Cognitive Ageing and Cognitive Epidemiology; Washington University in St. Louis; European Commission; Wellcome Trust; National Science Foundation; Massachusetts General Hospital; Rivierduinen; Pfizer; McDonnell Center for Systems Neuroscience; University of California, San Diego; Johns Hopkins University; Chinese Society of Clinical Oncology; Amgen","keywords":"Depression (economics); Association (psychology); Obesity; Medicine; Genome-wide association study; Psychiatry; Psychology; Genetics; Biology; Internal medicine; Single-nucleotide polymorphism; Genotype; Gene; Psychotherapist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005588005,0.0003423063,0.000337406,0.0007910813,0.0003492263,0.0004678208,0.0003507695,0.0003758254,0.001400712],"category_scores_gemma":[0.002217574,0.0002478078,0.0004571555,0.001024546,0.0002813092,0.0001913162,0.0004678685,0.0003394781,0.00009254504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001862533,"about_ca_system_score_gemma":0.0001817452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00299795,"about_ca_topic_score_gemma":0.0048382,"domain_scores_codex":[0.9993495,0.000217018,0.00009591731,0.0001941841,0.00008987811,0.00005356814],"domain_scores_gemma":[0.9986163,0.0002518336,0.0008008208,0.0001190062,0.00009200964,0.000119932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000253664,0.00001827618,0.9957756,0.00001409394,0.0003275182,0.0001966648,0.00004689359,0.00007743401,0.00154776,0.00005319998,0.00009651313,0.001592351],"study_design_scores_gemma":[0.00001228455,0.00003552657,0.9989154,0.000008488511,0.00008502322,0.0003937679,0.00003860531,0.000274852,0.00009613256,0.00006677578,0.00007024266,0.000002939979],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989899,0.0002024584,0.0001705557,0.00006289263,0.000004785789,0.000006726144,0.0003576909,0.000003633646,0.0002013491],"genre_scores_gemma":[0.9993345,0.00008299679,0.0002155213,0.00002319487,0.000008270275,0.00000521955,0.0002822651,0.000002379187,0.000045603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00299795,"threshold_uncertainty_score":0.005960941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006178756694654128,"score_gpt":0.2343133093087598,"score_spread":0.2281345526141056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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