{"id":"W2766577090","doi":"10.1016/j.pnpbp.2017.10.011","title":"A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response in bipolar disorder: A multimodal genetic imaging study","year":2017,"lang":"en","type":"article","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Health, British Columbia; Ministero della Salute","keywords":"Psychology; White matter; Grey matter; Bipolar disorder; Fractional anisotropy; Antidepressant; Anterior cingulate cortex; Mood disorders; Neuroscience; Prefrontal cortex; Neuroimaging; Major depressive disorder; Lithium (medication); Mood; Internal medicine; Psychiatry; Medicine; Magnetic resonance imaging; Cognition; Anxiety; Hippocampus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007046651,0.0004565638,0.0004874792,0.00047327,0.0008723625,0.0002484967,0.0006689788,0.0001984738,0.00003380964],"category_scores_gemma":[0.0005024824,0.0003397475,0.00004282074,0.0003490236,0.001918711,0.0003022082,0.0005693924,0.001190192,0.00000573491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001005765,"about_ca_system_score_gemma":0.00004667782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001038551,"about_ca_topic_score_gemma":0.00001127798,"domain_scores_codex":[0.9942132,0.002421347,0.0004748339,0.001834395,0.0002498363,0.0008064486],"domain_scores_gemma":[0.9978148,0.001262843,0.0002325688,0.000419318,0.00002459407,0.0002458157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008487051,0.0008053783,0.9137239,0.00004523105,0.000008242879,0.001118607,0.0001247045,0.000005869945,0.06875083,0.000009778836,0.00007724787,0.006843155],"study_design_scores_gemma":[0.006631286,0.002546999,0.9881631,0.00002967048,0.00002179195,0.0003134336,0.00002548683,0.000490337,0.0007843959,0.0004355258,0.0002170112,0.0003409733],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856215,0.003110874,0.00000247516,0.007906974,0.001701452,0.001571433,0.00002751197,0.00005079914,0.000006952627],"genre_scores_gemma":[0.9890362,0.001214876,0.0000493969,0.009340483,0.0001224081,0.0001976522,4.185635e-7,0.00002606682,0.00001247448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07443918,"threshold_uncertainty_score":0.9999055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803115955099483,"score_gpt":0.3415540675549874,"score_spread":0.3235229080039926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}