{"id":"W2766586147","doi":"10.1083/jcb.201711047","title":"Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor","year":2018,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Rockefeller University","keywords":"Ectodomain; Insulin receptor; Autophosphorylation; Transmembrane protein; Chemistry; Receptor tyrosine kinase; Cell biology; Ligand (biochemistry); Signal transduction; Transmembrane domain; Biophysics; Receptor; Biochemistry; Biology; Kinase; Insulin; Protein kinase A; Insulin resistance","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011404,0.0001589116,0.00009718257,0.0001476142,0.0001312823,0.0002195107,0.0002357322,0.0003706354,0.0006587788],"category_scores_gemma":[0.00008830688,0.0001162375,0.0001620543,0.0001051703,0.0001414812,0.0002386498,0.0002413115,0.0004719502,0.0002205859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647076,"about_ca_system_score_gemma":0.0001331131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003649789,"about_ca_topic_score_gemma":0.0003564541,"domain_scores_codex":[0.9999529,0.000007640068,0.000003299597,0.00001058534,0.00001323837,0.00001227313],"domain_scores_gemma":[0.9999042,0.00003151785,0.00001847278,0.00001042237,0.00001439562,0.00002105565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002577714,0.000007574222,0.00007213894,0.00001924104,0.000001854858,0.00009643706,0.00001809025,0.00004896822,0.9992529,0.0001218881,0.00002443968,0.0003106132],"study_design_scores_gemma":[0.00002487761,0.0001273604,0.006719704,0.000013167,0.00001166205,0.000800989,0.0001103837,0.006289418,0.9843201,0.0001361982,0.001437325,0.000008882939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925895,0.0005610962,0.005377536,0.0001288295,0.00001849889,0.00001146555,0.0001297312,0.00006123872,0.001122172],"genre_scores_gemma":[0.9883409,0.0006495895,0.009013977,0.00006894363,0.000008482342,0.00002642876,0.0002119255,0.00002908145,0.001650785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006587788,"threshold_uncertainty_score":0.002203822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02297489450426156,"score_gpt":0.3157854518567883,"score_spread":0.2928105573525268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}