{"id":"W2766596563","doi":"10.1371/journal.ppat.1006700","title":"Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"CSIR - Institute of Microbial Technology; Indian Institute of Science Education and Research Mohali; The Wellcome Trust DBT India Alliance; Department of Biotechnology, Ministry of Science and Technology, India; Council of Scientific and Industrial Research, India; University of Nebraska Medical Center; University of Notre Dame; University of Washington; Hospital for Sick Children; Wellcome Trust; Helsingin Yliopisto","keywords":"Endosome; Cell biology; Salmonella enterica; Biology; Endocytic cycle; Vacuole; Host factor; Lipid bilayer fusion; Lysosome; Salmonella; Endomembrane system; Effector; Intracellular; Endocytosis; Bacteria; Biochemistry; Membrane; Virology; Virus; Cell; Golgi apparatus; Cytoplasm","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340268,0.0001730444,0.0001375208,0.00002240545,0.0004296515,0.00008715215,0.0004485625,0.0001172764,0.00004539144],"category_scores_gemma":[0.0001334963,0.0001393232,0.00009521761,0.00003546098,0.00004568773,0.000007942423,0.0001117628,0.00009908473,0.00005581454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001175464,"about_ca_system_score_gemma":0.00002355363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008392721,"about_ca_topic_score_gemma":0.00003130636,"domain_scores_codex":[0.998877,0.0000344617,0.0001900482,0.0004724088,0.000168957,0.0002570719],"domain_scores_gemma":[0.9984184,0.000005333713,0.0001186208,0.001250813,0.0000976779,0.0001091893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003935431,0.00005324982,0.004940401,0.00001609722,0.00003747637,0.000006431765,0.0002462017,0.000003577685,0.991945,0.0000301086,0.00001317334,0.00266889],"study_design_scores_gemma":[0.0002148623,0.000131825,0.1675673,0.00001826348,0.00002842531,0.000008404771,0.0000420472,0.0001453639,0.8077446,0.000007604044,0.02389278,0.0001985189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957901,0.00015642,0.002199369,0.0005146008,0.00008539867,0.0005451005,0.0001149821,0.00002733782,0.0005667326],"genre_scores_gemma":[0.9980766,0.0001084733,0.0004220667,0.0001285654,0.0003360568,0.00005936896,0.0005898117,0.00003709934,0.0002419679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1842004,"threshold_uncertainty_score":0.5681433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04892832466969041,"score_gpt":0.2681475204894759,"score_spread":0.2192191958197855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}