{"id":"W2766596563","doi":"10.1371/journal.ppat.1006700","title":"Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"CSIR - Institute of Microbial Technology; Indian Institute of Science Education and Research Mohali; The Wellcome Trust DBT India Alliance; Department of Biotechnology, Ministry of Science and Technology, India; Council of Scientific and Industrial Research, India; University of Nebraska Medical Center; University of Notre Dame; University of Washington; Hospital for Sick Children; Wellcome Trust; Helsingin Yliopisto","keywords":"Endosome; Cell biology; Salmonella enterica; Biology; Endocytic cycle; Vacuole; Host factor; Lipid bilayer fusion; Lysosome; Salmonella; Endomembrane system; Effector; Intracellular; Endocytosis; Bacteria; Biochemistry; Membrane; Virology; Virus; Cell; Golgi apparatus; Cytoplasm","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008663032,0.000238346,0.0001246867,0.0001561007,0.0001077191,0.00026269,0.000131425,0.0001955087,0.000737657],"category_scores_gemma":[0.00006639993,0.0001091794,0.0001972247,0.00004751964,0.0001147949,0.0001429519,0.0003196281,0.0002627654,0.000310774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002729766,"about_ca_system_score_gemma":0.0001554277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000465781,"about_ca_topic_score_gemma":0.0006926437,"domain_scores_codex":[0.9999254,0.00001127862,0.000006720889,0.00001337944,0.00001661449,0.00002671878],"domain_scores_gemma":[0.9999378,0.000007085937,0.00001522438,0.00000884838,0.000008043483,0.00002307671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004052344,0.000007736033,0.0001551853,0.00001663101,0.000002869384,0.00003316226,0.000004585918,0.00002913071,0.9992244,0.00008253358,0.00002036588,0.0003828997],"study_design_scores_gemma":[0.000009378301,0.0001861868,0.004814442,0.000007940284,0.00001489106,0.0002891039,0.00004272909,0.001528948,0.9903106,0.000046643,0.002743791,0.000005435561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957051,0.001004993,0.001960176,0.00007201834,0.00001571122,0.00001365969,0.0001078944,0.00007247963,0.001048065],"genre_scores_gemma":[0.9973422,0.0002443913,0.0008476578,0.00002546587,0.000002475175,0.000007339249,0.0001559849,0.00001026703,0.001364206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000737657,"threshold_uncertainty_score":0.002467752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04892832466969041,"score_gpt":0.2681475204894759,"score_spread":0.2192191958197855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}