{"id":"W2766607130","doi":"10.1038/s41467-017-01399-2","title":"Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Exploratory Research for Advanced Technology; Institute of Genetics; Japan Science and Technology Agency; Biotechnology and Biological Sciences Research Council; Medical Research Council; National Institute of Biomedical Innovation; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development","keywords":"Periplasmic space; ATP-binding cassette transporter; Transmembrane protein; Transmembrane domain; Bacterial outer membrane; Cyclic nucleotide-binding domain; Biology; Cell envelope; Transporter; Biochemistry; Membrane protein; Chemistry; Cell biology; Peptide sequence; Escherichia coli; Membrane; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003116826,0.0005678185,0.0008419918,0.0003520784,0.001011108,0.0009657793,0.001011521,0.001018201,0.003509056],"category_scores_gemma":[0.0006868336,0.0004120661,0.0001965519,0.0006255735,0.000358251,0.0006225324,0.0003761664,0.001563024,0.0004210088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001802473,"about_ca_system_score_gemma":0.002017661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01112004,"about_ca_topic_score_gemma":0.0190319,"domain_scores_codex":[0.9997734,0.00003530044,0.000009345731,0.00003385298,0.0001028772,0.00004529066],"domain_scores_gemma":[0.9997179,0.00006327379,0.00003444122,0.000009648483,0.00008482819,0.00008982014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005994083,0.002125214,0.03890474,0.004750853,0.001074492,0.006494167,0.002866623,0.07288807,0.5688745,0.01992725,0.1912287,0.08487126],"study_design_scores_gemma":[0.00420622,0.002116644,0.1454059,0.0007716445,0.0009618987,0.005451908,0.005844544,0.4803934,0.1216634,0.01135176,0.2211802,0.0006525602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613045,0.01082034,0.00289197,0.003956402,0.0003748022,0.00008427205,0.007246922,0.0008597573,0.0124609],"genre_scores_gemma":[0.9597281,0.005143049,0.007756216,0.0007113782,0.00007463335,0.000124614,0.02178027,0.0002196902,0.00446206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01112004,"threshold_uncertainty_score":0.02211058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229776736832433,"score_gpt":0.3085832887565341,"score_spread":0.2856056150732908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}