{"id":"W2766607130","doi":"10.1038/s41467-017-01399-2","title":"Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Exploratory Research for Advanced Technology; Institute of Genetics; Japan Science and Technology Agency; Biotechnology and Biological Sciences Research Council; Medical Research Council; National Institute of Biomedical Innovation; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development","keywords":"Periplasmic space; ATP-binding cassette transporter; Transmembrane protein; Transmembrane domain; Bacterial outer membrane; Cyclic nucleotide-binding domain; Biology; Cell envelope; Transporter; Biochemistry; Membrane protein; Chemistry; Cell biology; Peptide sequence; Escherichia coli; Membrane; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006706394,0.0001668756,0.0003602184,0.00006975637,0.0003629322,0.00002724857,0.001005322,0.0003982417,0.0004457011],"category_scores_gemma":[0.00003381346,0.000132769,0.0001514691,0.00008996003,0.0002539689,0.000135521,0.00005975809,0.0009168518,0.000008632464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002246974,"about_ca_system_score_gemma":0.00008304703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007896999,"about_ca_topic_score_gemma":0.002048754,"domain_scores_codex":[0.9990333,0.00002649197,0.0003219173,0.0002042931,0.0002365545,0.0001774403],"domain_scores_gemma":[0.9959889,0.0000440833,0.0002189654,0.003403018,0.0002369462,0.0001080612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009142662,0.0006376605,0.1618833,0.0001446541,0.0005966664,0.00003094304,0.002057094,0.000002968318,0.8164684,0.008955902,0.005706661,0.002601506],"study_design_scores_gemma":[0.00225761,0.00009419796,0.8251404,0.0002504545,0.0004983361,0.000007762197,0.0001610691,0.00005430032,0.03275488,0.001329802,0.1371985,0.0002527522],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814749,0.004327421,0.000098971,0.005372579,0.00056191,0.0004132929,0.0005289038,0.00006859427,0.007153395],"genre_scores_gemma":[0.9910924,0.0004252257,0.006161574,0.0003142737,0.0001142911,0.000004557619,0.0009760584,0.00002693517,0.0008846347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7837135,"threshold_uncertainty_score":0.5414162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229776736832433,"score_gpt":0.3085832887565341,"score_spread":0.2856056150732908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}