{"id":"W2766638261","doi":"10.1152/ajplung.00372.2017","title":"Autophagy and the unfolded protein response promote profibrotic effects of TGF-β<sub>1</sub> in human lung fibroblasts","year":2017,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; Hospital for Sick Children; University of Toronto; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Idiopathic pulmonary fibrosis; Fibronectin; Unfolded protein response; Autophagy; Transforming growth factor; Lung; Pulmonary fibrosis; ATG5; Cancer research; Chemistry; XBP1; Pathology; Fibrosis; Medicine; Immunology; Biology; Cell biology; Internal medicine; Cell; Endoplasmic reticulum; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005230493,0.0003059518,0.001178752,0.0001845134,0.0002119369,0.00002054554,0.0002599255,0.0001211468,0.000003316516],"category_scores_gemma":[0.0003029238,0.0002115949,0.0003103465,0.0001071682,0.002284751,0.0001086321,0.000216348,0.0004520518,6.688688e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004475909,"about_ca_system_score_gemma":0.000160814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006637203,"about_ca_topic_score_gemma":9.473379e-7,"domain_scores_codex":[0.9975217,0.000917121,0.0006002562,0.000377765,0.0001901469,0.0003929991],"domain_scores_gemma":[0.9979256,0.000165029,0.00101333,0.000552155,0.0001620244,0.0001818216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01965604,0.0001888655,0.00007345187,0.000762166,0.000272114,0.0002565471,0.0002975333,0.0000112475,0.9771546,0.0004315949,0.00001678721,0.0008790611],"study_design_scores_gemma":[0.005631741,0.009522964,0.09917072,0.001375352,0.0004010145,0.0002010095,0.00009193445,0.000779893,0.8810732,0.001497284,0.00001170486,0.0002431551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966193,0.001775684,0.00007452576,0.0004813378,0.00009635226,0.0009205786,0.000004741376,0.000008832791,0.00001865572],"genre_scores_gemma":[0.9993765,0.0001096974,0.0001445291,0.0001693639,0.0001129651,0.00003387171,0.000006908097,0.00003440173,0.00001174105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09909727,"threshold_uncertainty_score":0.8628591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00269874799561633,"score_gpt":0.2330334051977704,"score_spread":0.230334657202154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}