{"id":"W2766639084","doi":"10.1158/1940-6207.capr-17-0225","title":"NF-κB at the Crossroads of Normal Mammary Gland Biology and the Pathogenesis and Prevention of <i>BRCA1</i>-Mutated Breast Cancer","year":2017,"lang":"en","type":"review","venue":"Cancer Prevention Research","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Paracrine signalling; RANKL; Progenitor cell; Biology; Cancer research; Carcinogenesis; Population; Breast cancer; Mammary gland; Progesterone receptor; Cancer; Endocrinology; Cell biology; Receptor; Internal medicine; Stem cell; Estrogen receptor; Medicine; Activator (genetics); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002770965,0.0002774262,0.0008086198,0.0001086887,0.0003903987,0.00005629653,0.0006403084,0.0004153092,0.00009199902],"category_scores_gemma":[0.00011489,0.0001647361,0.0003277711,0.0001785039,0.001839027,0.00001070441,0.000960178,0.0003253906,0.000001583451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005748463,"about_ca_system_score_gemma":0.0009107788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004706401,"about_ca_topic_score_gemma":0.0005053816,"domain_scores_codex":[0.9966033,0.001554399,0.0005933075,0.0005815633,0.0002969634,0.0003705248],"domain_scores_gemma":[0.997816,0.000142333,0.0006864453,0.000848067,0.0004305459,0.00007656771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003318587,0.00004387282,0.0006378856,0.005078458,0.0006026506,0.000001943579,0.00005315239,0.000002809714,0.01319152,0.0001522103,0.0005239856,0.9793797],"study_design_scores_gemma":[0.005103657,0.0006671149,0.002964427,0.0103102,0.001349699,0.0002640281,0.00005318298,0.0000382672,0.01642398,0.001227165,0.9607934,0.0008048393],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01250522,0.9849637,0.0001347059,0.0001448685,0.0001374188,0.001318461,0.0006136298,0.000004534901,0.0001775147],"genre_scores_gemma":[0.008902874,0.9856501,0.00002690034,0.000008847607,0.0002204925,0.0007125053,0.0002849039,0.00003727759,0.004156051],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9785748,"threshold_uncertainty_score":0.677597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035107943340917,"score_gpt":0.4580599835383796,"score_spread":0.3545491892042879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}