{"id":"W2766643051","doi":"10.1016/j.jalz.2017.06.1394","title":"[P3–182]: PROPAGATIVE TOXIC Aβ OLIGOMER SUBCLASS IDENTIFIED AND DEFINED BY SOLVENT ORIENTATION OF THE LYSINE 28 SIDE CHAIN","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Center for Diagnosis and Research on Alzheimer's Disease; University of British Columbia","funders":"","keywords":"Epitope; Monoclonal antibody; Molecular biology; Chemistry; In vivo; Antibody; Epitope mapping; Biochemistry; Biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007171541,0.0003461373,0.0001737649,0.0001382355,0.0002303567,0.0001907031,0.0002338393,0.0002899053,0.003267167],"category_scores_gemma":[0.0000843493,0.0001117117,0.0002331541,0.000189056,0.0001866896,0.0002117157,0.000184538,0.0003902808,0.001500751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001461085,"about_ca_system_score_gemma":0.0002349624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008840354,"about_ca_topic_score_gemma":0.0007366465,"domain_scores_codex":[0.9999402,0.000004320023,0.00000531821,0.00002228595,0.00001285486,0.00001502579],"domain_scores_gemma":[0.9999332,0.000003303871,0.0000207751,0.000007606882,0.00001299869,0.00002213179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002377877,0.00004866914,0.0006974502,0.00004783223,0.000008951817,0.0002394017,0.00001653331,0.00007940493,0.9951238,0.0002726453,0.0003288843,0.002898732],"study_design_scores_gemma":[0.0001168728,0.001734789,0.03262056,0.0000301835,0.00006921682,0.005900205,0.00009148112,0.001738814,0.9163989,0.001074073,0.04019104,0.00003384121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833746,0.0006381422,0.005180826,0.0001131928,0.00006769031,0.00009093755,0.001496816,0.0001154935,0.008922401],"genre_scores_gemma":[0.975175,0.0008209857,0.006366902,0.0002803904,0.00004706723,0.00009428905,0.00331688,0.0001268645,0.01377171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003267167,"threshold_uncertainty_score":0.01092976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03041945560036824,"score_gpt":0.3103206706855038,"score_spread":0.2799012150851356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}