{"id":"W2766644732","doi":"10.1152/ajpendo.00172.2017","title":"Genetic ablation of<i>Cyp8b1</i>preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition","year":2017,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada; Eli Lilly and Company; Universitätsklinikum Erlangen; Alexander von Humboldt-Stiftung","keywords":"Composition (language); Biology; Function (biology); Steatohepatitis; Gut flora; Cell biology; Genetics; Biochemistry; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899967,0.0007029411,0.0003995411,0.0005340602,0.0002725864,0.0005960944,0.0003724864,0.0004840721,0.004381966],"category_scores_gemma":[0.000129706,0.0002667127,0.000406341,0.0002398533,0.0005001044,0.0002446423,0.0002864925,0.001141429,0.001842822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003434439,"about_ca_system_score_gemma":0.0002556143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008395351,"about_ca_topic_score_gemma":0.001096937,"domain_scores_codex":[0.999718,0.00003930064,0.00002691415,0.0000930243,0.00006399518,0.00005873334],"domain_scores_gemma":[0.9996493,0.00002173357,0.000125977,0.00004625049,0.00002807482,0.0001286872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000201551,0.00004051304,0.000312824,0.00002856081,0.0000099948,0.00004785189,0.000008983665,0.00004442881,0.9977589,0.0001897446,0.0001417671,0.001214841],"study_design_scores_gemma":[0.0000769551,0.0004139452,0.01132427,0.00001796485,0.00004975262,0.0008233006,0.00007159138,0.001002213,0.9756377,0.000176151,0.01038952,0.00001666758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763426,0.001501727,0.01242009,0.000778358,0.0001995495,0.0000607246,0.003731749,0.0008719349,0.004093314],"genre_scores_gemma":[0.969771,0.001192274,0.006439034,0.0003408067,0.00005787453,0.0001531191,0.00346272,0.0006106138,0.01797255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004381966,"threshold_uncertainty_score":0.01465911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00889295835127686,"score_gpt":0.2552586714023754,"score_spread":0.2463657130510986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}