{"id":"W2766647922","doi":"10.1016/j.str.2017.09.009","title":"Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences; Canada Research Chairs; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Epitope; Antibody-dependent cell-mediated cytotoxicity; Immunogenicity; Antibody; HIV vaccine; Virology; Biology; AIDS Vaccines; Cytotoxicity; Vaccine trial; Human immunodeficiency virus (HIV); Cell biology; Immunology; In vitro; Genetics; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944691,0.0003692871,0.0001664498,0.00008733843,0.0004132198,0.0005197206,0.0003777794,0.0004633353,0.001406949],"category_scores_gemma":[0.0001971888,0.0001497915,0.0002525662,0.00006301497,0.0003857033,0.0003746797,0.0001997314,0.0007942205,0.0003846989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006921709,"about_ca_system_score_gemma":0.000533807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103959,"about_ca_topic_score_gemma":0.001244218,"domain_scores_codex":[0.9999239,0.00001352519,0.000004055531,0.00001238812,0.00001723547,0.00002875568],"domain_scores_gemma":[0.9998938,0.00002674697,0.00002207853,0.00001080467,0.00002350106,0.00002309584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002815234,0.0000705225,0.0004438436,0.00003552115,0.000006018126,0.0002365507,0.00004357571,0.001515934,0.9914576,0.003471188,0.0001457962,0.002291854],"study_design_scores_gemma":[0.00006463406,0.0005369978,0.004444487,0.00002081873,0.00002167577,0.0007606061,0.0001068953,0.01074488,0.9785429,0.0009423733,0.003794848,0.00001894088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869376,0.0005578848,0.008953119,0.0003093165,0.00003749766,0.00003240256,0.00006112635,0.00003442121,0.003076662],"genre_scores_gemma":[0.9959875,0.0002514474,0.002306701,0.0001103802,0.00000786788,0.000006537948,0.00008864596,0.000008507857,0.001232397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001406949,"threshold_uncertainty_score":0.005022109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661304793008308,"score_gpt":0.2871801591706434,"score_spread":0.2705671112405604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}