{"id":"W2766647922","doi":"10.1016/j.str.2017.09.009","title":"Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences; Canada Research Chairs; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Epitope; Antibody-dependent cell-mediated cytotoxicity; Immunogenicity; Antibody; HIV vaccine; Virology; Biology; AIDS Vaccines; Cytotoxicity; Vaccine trial; Human immunodeficiency virus (HIV); Cell biology; Immunology; In vitro; Genetics; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000275105,0.0001715535,0.0002459292,0.0000430073,0.0007698717,0.0000527105,0.0006458025,0.0001746081,0.0001117364],"category_scores_gemma":[0.0002530966,0.00008737944,0.000126681,0.00003028608,0.0002549117,0.0000804244,0.00009657893,0.0002640972,0.000006421054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002992004,"about_ca_system_score_gemma":0.00004895399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001504214,"about_ca_topic_score_gemma":0.000109945,"domain_scores_codex":[0.9988995,0.0001701025,0.0002233036,0.0002258683,0.00006321381,0.0004180696],"domain_scores_gemma":[0.9988656,0.0002907687,0.0002190984,0.0005485023,0.00006018749,0.0000158494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007169981,0.00003867763,0.029014,0.0001716265,0.0003365364,0.00002118151,0.002943047,0.00007684505,0.9585183,0.002643461,0.001853167,0.00366614],"study_design_scores_gemma":[0.005991437,0.0005753854,0.0618435,0.00008518099,0.000128039,0.000030714,0.003531044,0.0001104791,0.8902966,0.004382779,0.0326434,0.0003813811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937812,0.001082215,0.0003510407,0.001198346,0.0002663527,0.001314284,0.00189253,0.000009855836,0.0001041545],"genre_scores_gemma":[0.9969788,0.00006731971,0.0001308887,0.00005270953,0.00007621961,0.00005889676,0.0005045009,0.00001377051,0.002116877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06822166,"threshold_uncertainty_score":0.5921308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661304793008308,"score_gpt":0.2871801591706434,"score_spread":0.2705671112405604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}