{"id":"W2766733089","doi":"10.1186/s12977-017-0370-5","title":"Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain","year":2017,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Hospitalier Universitaire Sainte-Justine; University of Alberta; Université de Montréal; McGill University; University of Calgary; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Gilead Sciences","keywords":"Microglia; Medicine; In vivo; Drug; Peripheral blood mononuclear cell; Immunology; Human brain; Viral load; Virology; In vitro; Pharmacology; Biology; Human immunodeficiency virus (HIV); Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001614456,0.0001983784,0.0002707457,0.0002381215,0.0002066982,0.0005466523,0.0001827449,0.0002640797,0.001456123],"category_scores_gemma":[0.0002668872,0.0001151868,0.0001386323,0.000149059,0.0002818846,0.000204776,0.0001836558,0.0004329995,0.00023513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696791,"about_ca_system_score_gemma":0.0001863625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003553958,"about_ca_topic_score_gemma":0.000526774,"domain_scores_codex":[0.9998773,0.00002718999,0.00001151666,0.00001868502,0.00003469507,0.00003054887],"domain_scores_gemma":[0.9997647,0.00004814311,0.00008387982,0.000018094,0.00005076504,0.00003431353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009818653,0.0001494938,0.01461406,0.0002842426,0.00006696879,0.000440812,0.0001069198,0.000175512,0.9627886,0.0002274843,0.000209871,0.0199541],"study_design_scores_gemma":[0.00006414073,0.002370022,0.2116376,0.0001459415,0.0002620599,0.00564782,0.0003216627,0.002044518,0.7706732,0.001148511,0.005661077,0.00002352907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896685,0.007835371,0.000725589,0.0001503235,0.00001399395,0.00001957004,0.0001694915,0.00002431732,0.001392768],"genre_scores_gemma":[0.9963498,0.002038625,0.0008307804,0.00006407073,0.00003110263,0.00002494352,0.0001582957,0.000006784435,0.000495619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456123,"threshold_uncertainty_score":0.00487119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321981137822067,"score_gpt":0.2712741528217636,"score_spread":0.258054341443543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}