{"id":"W2766745670","doi":"10.1182/blood-2017-07-793760","title":"Infectious complications of CD19-targeted chimeric antigen receptor–modified T-cell immunotherapy","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":566,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Juno Therapeutics; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Washington State University","keywords":"Chimeric antigen receptor; Immunotherapy; Medicine; CD19; Antigen; Immunology; Virology; Cancer research; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00147506,0.0002953995,0.0007025239,0.0001600936,0.0002020782,0.0005917357,0.0002376058,0.0002827845,0.003252456],"category_scores_gemma":[0.003071875,0.0001567851,0.001266197,0.0002845003,0.0001544835,0.0003588311,0.0004331384,0.001404022,0.0001902705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003267422,"about_ca_system_score_gemma":0.0006106072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000618454,"about_ca_topic_score_gemma":0.000846809,"domain_scores_codex":[0.9989763,0.0004063947,0.0001049794,0.0001086084,0.000200367,0.0002032634],"domain_scores_gemma":[0.9961808,0.001575691,0.001376679,0.0003244587,0.0001682781,0.0003741308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05401473,0.001920654,0.7643476,0.0007573632,0.004543375,0.003092309,0.0001426516,0.00353261,0.006955225,0.00104065,0.003989758,0.155663],"study_design_scores_gemma":[0.0009270134,0.00953772,0.9654205,0.0001416715,0.002158655,0.004207913,0.0001002774,0.007854798,0.002623713,0.0008219693,0.006174407,0.00003139687],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903266,0.004436703,0.001954277,0.0001759053,0.0000807364,0.0001113782,0.000367668,0.00002594813,0.002520747],"genre_scores_gemma":[0.9978795,0.0005294741,0.000263373,0.00007712168,0.00006891348,0.00003001702,0.0003199066,0.000007690146,0.0008241546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003252456,"threshold_uncertainty_score":0.01088053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03004911792305832,"score_gpt":0.3166894952938824,"score_spread":0.286640377370824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}