{"id":"W2766782573","doi":"10.1212/wnl.0000000000004643","title":"In vivo staging of regional amyloid deposition","year":2017,"lang":"en","type":"article","venue":"Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":452,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Deutsches Zentrum für Neurodegenerative Erkrankungen; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Amyloid (mycology); Deposition (geology); Sequence (biology); Amyloid β; In vivo; Degenerative disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001576948,0.0006161721,0.0003325162,0.0009895571,0.000186641,0.0005942944,0.000412474,0.0004806542,0.0009234463],"category_scores_gemma":[0.002507527,0.0002420525,0.0002901116,0.0003484898,0.0002621426,0.0005963717,0.0003200468,0.0003234899,0.0002582363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205495,"about_ca_system_score_gemma":0.0002040965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001519772,"about_ca_topic_score_gemma":0.002503942,"domain_scores_codex":[0.9995641,0.0001516697,0.00003885672,0.0001654452,0.00005453828,0.00002537166],"domain_scores_gemma":[0.9988235,0.0002684224,0.0005007642,0.000188318,0.0001662745,0.00005278987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008016548,0.00009364159,0.8755971,0.0001430762,0.0002512284,0.0001993865,0.0004402755,0.00477575,0.09888057,0.0002288709,0.0001309673,0.01845741],"study_design_scores_gemma":[0.00002376383,0.0006551244,0.9492174,0.00002631817,0.0001495629,0.00152163,0.0001916055,0.02068422,0.02622278,0.000691668,0.0005935595,0.00002231763],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810822,0.0004583325,0.01738283,0.00001767687,0.000004269648,0.00005563307,0.0003715773,0.00008003647,0.0005473177],"genre_scores_gemma":[0.9914766,0.0001213225,0.007784385,0.000008401668,0.000004121825,0.00003295625,0.0003244836,0.00001227225,0.0002354216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001576948,"threshold_uncertainty_score":0.008339763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02579855063870392,"score_gpt":0.3353061028220876,"score_spread":0.3095075521833837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}