{"id":"W2766822678","doi":"10.1007/s00232-017-9994-6","title":"CmpX Affects Virulence in Pseudomonas aeruginosa Through the Gac/Rsm Signaling Pathway and by Modulating c-di-GMP Levels","year":2017,"lang":"en","type":"article","venue":"The Journal of Membrane Biology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Pseudomonas aeruginosa; Virulence; Biofilm; Microbiology; Biology; Mutant; Response regulator; Quorum sensing; Sigma factor; Guanosine monophosphate; Virulence factor; Bacterial outer membrane; Signal transduction; Cell biology; Bacteria; Gene expression; Biochemistry; Gene; Escherichia coli; Genetics; Promoter; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450216,0.0003316114,0.0001992128,0.0001633067,0.0001750993,0.0003560985,0.0002589244,0.0005466077,0.001065137],"category_scores_gemma":[0.0001790227,0.0001708502,0.0002068723,0.0001373057,0.0003440501,0.0002632193,0.0003098829,0.0008275026,0.0002329174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005939303,"about_ca_system_score_gemma":0.0003565066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001796909,"about_ca_topic_score_gemma":0.001765421,"domain_scores_codex":[0.9997607,0.00005168301,0.00001614309,0.00002604581,0.00006850334,0.00007693765],"domain_scores_gemma":[0.9998964,0.0000199717,0.00002814995,0.00001051927,0.00001193607,0.00003302676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001355273,0.00001922858,0.00007349137,0.000009991487,0.000001580815,0.00002326416,0.000004973233,0.00002661887,0.9993294,0.00006262177,0.00001778717,0.0002955278],"study_design_scores_gemma":[0.00002427639,0.0002110595,0.006704553,0.000004355502,0.0000119733,0.00008615999,0.00003660364,0.00122066,0.9910187,0.0001066628,0.0005688976,0.000006241075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997769,0.0004508662,0.000636891,0.0002509352,0.00001645621,0.000009087591,0.0001718047,0.00003610269,0.000658915],"genre_scores_gemma":[0.9981516,0.0001925985,0.0004958246,0.0000530316,0.000003953156,0.00001297041,0.0001049117,0.000009020398,0.0009760759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001796909,"threshold_uncertainty_score":0.004309297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.020009216898731,"score_gpt":0.2665264945359596,"score_spread":0.2465172776372286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}