{"id":"W2766855729","doi":"10.3233/jpd-171240","title":"Is the Enzyme ACMSD a Novel Therapeutic Target in Parkinson’s Disease?","year":2017,"lang":"en","type":"review","venue":"Journal of Parkinson s Disease","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Deafness and Other Communication Disorders; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institutes of Health; Alzheimer's Society; Brain and Behavior Research Foundation; Michael J. Fox Foundation for Parkinson's Research; Scottish Rite Charitable Foundation of Canada; U.S. Department of Defense","keywords":"Quinolinic acid; Parkinson's disease; Biology; Kynurenine pathway; Neurotoxin; Genetics; Pathogenesis; Enzyme; Somatic hypermutation; Gene; Cell biology; Biochemistry; Disease; Kynurenine; Tryptophan; Immunology; Medicine; Amino acid; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008265709,0.0008082545,0.001791754,0.000544382,0.0003848249,0.0004950133,0.003107547,0.0002148344,0.0003308919],"category_scores_gemma":[0.001822421,0.0004945367,0.002046144,0.0004919413,0.0004259151,0.0004690435,0.0002544442,0.001303823,0.0001384074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273279,"about_ca_system_score_gemma":0.001949648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006349274,"about_ca_topic_score_gemma":0.000004898594,"domain_scores_codex":[0.9949925,0.000742882,0.001475069,0.0007841925,0.001244529,0.0007608524],"domain_scores_gemma":[0.9941439,0.0007998415,0.002543156,0.001451682,0.00008939839,0.0009720285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001071538,0.002875935,0.001482789,0.009399458,0.0003435653,0.002986328,0.0005493272,0.00003156509,0.00005144859,0.0008323951,0.02162725,0.9587484],"study_design_scores_gemma":[0.0009369414,0.00005136691,0.004971576,0.005140544,0.0004961134,0.00005770881,0.00002220728,0.00005428703,0.000008802393,0.0009935915,0.9867147,0.0005521353],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001861744,0.9951918,0.00007025077,0.001772046,0.001070903,0.0009318945,0.0004449665,0.0000266796,0.0003053171],"genre_scores_gemma":[0.01812885,0.9775413,0.00003795491,0.002785003,0.0006969501,0.00008353269,0.00000697195,0.0001190124,0.0006004564],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9650875,"threshold_uncertainty_score":0.9997506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1392048481912177,"score_gpt":0.3699734395271527,"score_spread":0.230768591335935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}