{"id":"W2766888414","doi":"10.1021/acs.jmedchem.7b01102","title":"Noncovalent Protein Arginine Deiminase (PAD) Inhibitors Are Efficacious in Animal Models of Multiple Sclerosis","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Canada Research Chairs; University Health Network; University of Toronto","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Chemistry; Pharmacology; Hydantoin; Multiple sclerosis; In vivo; Moiety; Pharmacokinetics; Potency; Arginine; Biochemistry; Stereochemistry; Amino acid; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414828,0.0003977868,0.0004124213,0.0002493419,0.0001122731,0.0001558123,0.0002460179,0.0001959043,0.0008188604],"category_scores_gemma":[0.00007402681,0.0001089919,0.0001497059,0.000188712,0.0002164671,0.0001733014,0.00008878759,0.0005679208,0.0001756977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171171,"about_ca_system_score_gemma":0.000182763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003556811,"about_ca_topic_score_gemma":0.001354453,"domain_scores_codex":[0.999926,0.00001596138,0.000004927254,0.00001440258,0.00001778467,0.00002096822],"domain_scores_gemma":[0.999941,0.000008671639,0.0000226448,0.000004608627,0.000006764411,0.00001624519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003322447,0.0001422367,0.00007521713,0.00009013875,0.00001622771,0.0000686915,0.00001141176,0.0002582613,0.992855,0.0001684391,0.00009471177,0.005887443],"study_design_scores_gemma":[0.0001442446,0.004330552,0.001389588,0.000006901912,0.00003754751,0.0002007108,0.000008947552,0.0004580964,0.9903743,0.00005782842,0.002983296,0.000007913248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868392,0.004881417,0.004772743,0.0001053862,0.00005060051,0.0001509879,0.0003746746,0.0002089686,0.002615938],"genre_scores_gemma":[0.9902177,0.003831173,0.003387557,0.00006065363,0.000023957,0.00007395453,0.0003530815,0.00001768581,0.002034064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008188604,"threshold_uncertainty_score":0.00273931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03543560934079566,"score_gpt":0.2583517363293605,"score_spread":0.2229161269885649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}