{"id":"W2766902410","doi":"10.1093/femsre/fux054","title":"Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems","year":2017,"lang":"en","type":"review","venue":"FEMS Microbiology Reviews","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Synthetic lethality; Chemical genetics; Lethality; Genomics; Biology; Context (archaeology); Computational biology; Drug discovery; Functional genomics; Synthetic biology; Genetics; Gene; Genome; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005720609,0.0004171638,0.002456839,0.00008830944,0.00002508682,0.00001643964,0.0003438211,0.000667301,0.000008506865],"category_scores_gemma":[0.0002949527,0.00032336,0.0003319631,0.00006723014,0.0004296528,0.000003784271,0.0002181727,0.0002186245,0.000008126826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001620347,"about_ca_system_score_gemma":0.0001009747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001477676,"about_ca_topic_score_gemma":0.00001071376,"domain_scores_codex":[0.9973621,0.0005028599,0.00122596,0.0006336916,0.00002575773,0.000249633],"domain_scores_gemma":[0.9979268,0.00001574645,0.001077607,0.0008699369,0.00006010957,0.00004975484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002014915,0.00009240577,0.00002106621,0.02341413,0.00006520643,9.077634e-7,0.00001107985,5.172104e-7,0.887128,0.000008657308,0.0003059094,0.08893197],"study_design_scores_gemma":[0.000142413,0.00008397515,0.00001331807,0.005303338,0.0002008101,0.0002128036,9.072945e-7,2.553546e-7,0.01647535,0.000001427222,0.9772872,0.000278259],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05357971,0.9444636,0.00001065955,0.000002773608,0.0004412143,0.001240854,0.0002404322,0.000004321093,0.00001642022],"genre_scores_gemma":[0.001623732,0.9967055,0.00063919,0.000003540964,0.0002521818,0.00006119122,0.000507662,0.00003125812,0.0001757316],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9769812,"threshold_uncertainty_score":0.9999219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1254696995387309,"score_gpt":0.3260382645726877,"score_spread":0.2005685650339568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}