{"id":"W2767001703","doi":"10.1016/j.jval.2017.08.2959","title":"Comparative Effectiveness of Secukinumab and Adalimumab in Ankylosing Spondylitis as Assessed by Matching-Adjusted Indirect Comparison: An Analysis Based on All Pivotal Phase 3 Clinical Trial Data","year":2017,"lang":"en","type":"article","venue":"Value in Health","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Secukinumab; Adalimumab; BASFI; Ankylosing spondylitis; Placebo; Odds ratio; Internal medicine; BASDAI; Logistic regression; Tumor necrosis factor alpha; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03542393,0.001951997,0.006980652,0.001429824,0.0004036541,0.001562796,0.00166143,0.001705825,0.004363855],"category_scores_gemma":[0.03951963,0.0009516462,0.01165477,0.001439497,0.001216411,0.002115821,0.001486913,0.002513978,0.0002859394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008150045,"about_ca_system_score_gemma":0.0006619381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007756719,"about_ca_topic_score_gemma":0.001046411,"domain_scores_codex":[0.9457513,0.04670534,0.002585503,0.002359216,0.001705996,0.0008926111],"domain_scores_gemma":[0.9566252,0.03508403,0.003798143,0.003336993,0.0006496191,0.0005060401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8030072,0.0005179298,0.01734421,0.00273454,0.1502703,0.0001019835,0.0001276579,0.003448558,0.000853969,0.0006336151,0.0003814574,0.02057857],"study_design_scores_gemma":[0.3962244,0.08813883,0.09226034,0.0007625521,0.3869168,0.0005317185,0.0003120014,0.02131968,0.003017494,0.006956024,0.003284624,0.0002755249],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586933,0.02843684,0.00681669,0.0002856411,0.0005668799,0.0011315,0.001756775,0.00008049849,0.002231966],"genre_scores_gemma":[0.9950905,0.001343066,0.001917868,0.0001693639,0.00008737858,0.0003880851,0.0006245535,0.00002086087,0.0003582245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03542393,"threshold_uncertainty_score":0.1873419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2702468529887924,"score_gpt":0.5160331448616927,"score_spread":0.2457862918729004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}