{"id":"W2767028946","doi":"10.1128/mcb.00295-17","title":"Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration","year":2017,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Eye Institute; University of Pennsylvania","keywords":"RPE65; Retinal pigment epithelium; Biology; Retinal degeneration; Cell biology; Visual phototransduction; Macular degeneration; Retina; Retinal; Extracellular; Kinase; Signal transduction; Cancer research; Neuroscience; Biochemistry; Ophthalmology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759057,0.0003298601,0.000262513,0.0003791342,0.0001662744,0.0002659903,0.0001733594,0.0003729081,0.001433101],"category_scores_gemma":[0.0001350573,0.0001782943,0.0003474959,0.0001724229,0.0002448124,0.0002280353,0.0002396076,0.0006787644,0.0003872132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002092383,"about_ca_system_score_gemma":0.0001914786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004805839,"about_ca_topic_score_gemma":0.0004658138,"domain_scores_codex":[0.9997981,0.00003845264,0.00003054567,0.0000396096,0.00004952664,0.00004372528],"domain_scores_gemma":[0.9998748,0.00001696599,0.00004310298,0.00001957606,0.000011225,0.00003420931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001281954,0.00003830175,0.0002118754,0.00002392078,0.00000599956,0.0001319648,0.000006416621,0.0000209316,0.9985347,0.00008484609,0.00002820969,0.0007846348],"study_design_scores_gemma":[0.00002595043,0.0003329291,0.01160787,0.000009230135,0.00002958907,0.001128828,0.00004735518,0.0005321418,0.9841584,0.0001163341,0.002006018,0.000005286014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911271,0.003857945,0.002736118,0.0001970121,0.00005458853,0.0000238896,0.0002661677,0.0001333142,0.001604031],"genre_scores_gemma":[0.994896,0.001121423,0.001227446,0.00008146009,0.000006462428,0.00002501534,0.0001820511,0.00002080088,0.002439349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433101,"threshold_uncertainty_score":0.00479424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007868286354519296,"score_gpt":0.2366012108205345,"score_spread":0.2287329244660151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}