{"id":"W2767031674","doi":"10.1016/j.drup.2017.10.003","title":"Not only P-glycoprotein: Amplification of the ABCB1- containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins","year":2017,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministry of Health, British Columbia; Sapienza Università di Roma; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Multiple drug resistance; Biology; Efflux; P-glycoprotein; Cancer cell; Cancer research; Drug resistance; ATP-binding cassette transporter; Epigenetics; Locus (genetics); Vinca; Gene; Cancer; Genetics; Pharmacology; Transporter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413089,0.0003768212,0.0003789134,0.0005846114,0.0002535948,0.0006414745,0.0001742605,0.0005147622,0.003974085],"category_scores_gemma":[0.0003114853,0.0001960164,0.0002550242,0.000569445,0.0002743511,0.0004136456,0.0004028059,0.0006825087,0.001909146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002946055,"about_ca_system_score_gemma":0.0002274149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004043172,"about_ca_topic_score_gemma":0.0004903348,"domain_scores_codex":[0.9996837,0.0000374594,0.00002128092,0.0000927474,0.0001322545,0.00003246962],"domain_scores_gemma":[0.9998073,0.00002894515,0.00005006562,0.00002953026,0.00004701633,0.00003725403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005812112,0.00002348682,0.002080813,0.00005831961,0.00002215178,0.0005734431,0.0000302311,0.00005793916,0.9874526,0.0002590182,0.0005663264,0.008817584],"study_design_scores_gemma":[0.0000515744,0.000648715,0.1049533,0.00002657018,0.0002034707,0.01726383,0.0001209036,0.001412853,0.8091654,0.001060994,0.06504806,0.00004433953],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9602315,0.01576968,0.008964671,0.002188327,0.0002170533,0.00007616598,0.001664825,0.0005589132,0.01032879],"genre_scores_gemma":[0.979131,0.007765396,0.001810851,0.0003006593,0.0000923425,0.00007282711,0.001885369,0.00008010111,0.008861512],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003974085,"threshold_uncertainty_score":0.01329464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03416051113123444,"score_gpt":0.3147363883626371,"score_spread":0.2805758772314026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}