{"id":"W2767033809","doi":"10.1002/pmic.201700296","title":"Proteomic Screen of Brain Glycoproteome Reveals Prion Specific Marker of Pathogenesis","year":2017,"lang":"en","type":"article","venue":"PROTEOMICS","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Public Health Agency of Canada","keywords":"Biology; Glial fibrillary acidic protein; Proteome; Astrogliosis; Wheat germ agglutinin; Scrapie; Proteomics; Pathology; Western blot; Progressive supranuclear palsy; Neuroinflammation; Molecular biology; Lectin; Prion protein; Disease; Immunology; Biochemistry; Gene; Neuroscience; Central nervous system; Medicine; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006404964,0.0002132697,0.0003395717,0.00006134811,0.0001773601,0.00004157056,0.0006856011,0.00021062,0.00005656052],"category_scores_gemma":[0.0004418468,0.0002103981,0.0002231624,0.00005037132,0.0001998159,0.00001381538,0.0003862218,0.00009169475,0.000006823737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001693045,"about_ca_system_score_gemma":0.0001273752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005197817,"about_ca_topic_score_gemma":0.000003693616,"domain_scores_codex":[0.9985088,0.00009449484,0.000472492,0.0004199051,0.0002147194,0.0002896411],"domain_scores_gemma":[0.9977254,0.0000101212,0.0007276608,0.001257911,0.0001662846,0.0001126815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005204787,0.00005279192,0.0126775,0.000135818,0.00004909066,0.000002198779,0.00002222768,0.000009439099,0.9537666,0.0001150998,0.0003021167,0.03234662],"study_design_scores_gemma":[0.0008033184,0.0002429225,0.06736121,0.0001312766,0.00001743943,0.000007395525,0.00001266987,0.00002677725,0.9263,0.0009102219,0.003927233,0.0002594727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918895,0.001880167,0.003753995,0.0003053184,0.00008163631,0.001669362,0.0001655064,0.000009714355,0.00024483],"genre_scores_gemma":[0.9730784,0.001771004,0.02442272,0.00005111764,0.0002166483,0.0001420853,0.00004975931,0.00004356742,0.0002247092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0546837,"threshold_uncertainty_score":0.8579783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520981138672196,"score_gpt":0.2630953370991543,"score_spread":0.2478855257124323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}