{"id":"W2767033809","doi":"10.1002/pmic.201700296","title":"Proteomic Screen of Brain Glycoproteome Reveals Prion Specific Marker of Pathogenesis","year":2017,"lang":"en","type":"article","venue":"PROTEOMICS","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Public Health Agency of Canada","keywords":"Biology; Glial fibrillary acidic protein; Proteome; Astrogliosis; Wheat germ agglutinin; Scrapie; Proteomics; Pathology; Western blot; Progressive supranuclear palsy; Neuroinflammation; Molecular biology; Lectin; Prion protein; Disease; Immunology; Biochemistry; Gene; Neuroscience; Central nervous system; Medicine; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078991,0.0004069803,0.0002751592,0.0004391508,0.0001737765,0.0001869256,0.000125205,0.0002545779,0.0005515392],"category_scores_gemma":[0.0001110639,0.0001002495,0.0002174984,0.0002641409,0.0001029094,0.0001542013,0.0001834283,0.0002618241,0.0001983907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001134279,"about_ca_system_score_gemma":0.00009048569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000294023,"about_ca_topic_score_gemma":0.0004431827,"domain_scores_codex":[0.9999448,0.000006686866,0.000004241676,0.00001623467,0.00001460951,0.0000132624],"domain_scores_gemma":[0.9999533,0.00000572371,0.00001244715,0.000002868157,0.00001118741,0.00001451726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001116043,0.00002086758,0.0009938508,0.00003420513,0.00001014043,0.0001152403,0.00001678837,0.00001504346,0.9976904,0.00002081467,0.00003470434,0.0009364423],"study_design_scores_gemma":[0.00002927218,0.00079075,0.1953091,0.00002265882,0.0001112726,0.00322219,0.000168213,0.001792665,0.7949898,0.000279253,0.003264165,0.00002070356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949063,0.001489194,0.002017699,0.00007294684,0.00001289147,0.00003471036,0.0007500251,0.00003216594,0.0006840919],"genre_scores_gemma":[0.9830188,0.002562675,0.008347626,0.0001409895,0.00001785627,0.00008245952,0.003448555,0.00001782571,0.00236325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005515392,"threshold_uncertainty_score":0.001845121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520981138672196,"score_gpt":0.2630953370991543,"score_spread":0.2478855257124323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}