{"id":"W2767038038","doi":"10.1128/jvi.01281-17","title":"Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion","year":2017,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Fonds de Recherche du Québec - Santé; Genome Canada","keywords":"Biology; Herpes simplex virus; Synaptotagmin 1; Virology; Glycoprotein; Lipid bilayer fusion; Virus; Membrane glycoproteins; Fusion; Alphaherpesvirinae; Viral membrane; Herpesvirus glycoprotein B; Viral entry; Membrane; Herpesviridae; Viral replication; Molecular biology; Genetics; Vesicle; Viral envelope; Synaptic vesicle; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001315093,0.00020949,0.0002368314,0.0001853397,0.0001664668,0.00030793,0.0001783369,0.0002576379,0.0009247247],"category_scores_gemma":[0.0001668848,0.0001026259,0.0001605682,0.0001518283,0.0001902573,0.0001800325,0.0002950662,0.0003874401,0.0002303769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002837838,"about_ca_system_score_gemma":0.0001079523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003352152,"about_ca_topic_score_gemma":0.0003750423,"domain_scores_codex":[0.9998424,0.00002919719,0.00001172043,0.0000224409,0.00004097756,0.00005328379],"domain_scores_gemma":[0.9999231,0.00002089052,0.00001617944,0.000005859116,0.000009154861,0.00002471416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001348223,0.00002015948,0.0002258608,0.0000217529,0.000005548432,0.00003243331,0.000007568894,0.00002108046,0.9991443,0.0000418263,0.00002100863,0.0003235844],"study_design_scores_gemma":[0.00003384394,0.000364257,0.02953742,0.00001444821,0.00002496405,0.0002701943,0.00006858265,0.001622963,0.966341,0.0000983137,0.001616699,0.000007263387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978232,0.001165036,0.0002959056,0.00003822164,0.00001465066,0.000008311397,0.0000967806,0.000008963038,0.0005489016],"genre_scores_gemma":[0.9987317,0.0003148887,0.0001602227,0.00002769009,0.000003908387,0.00001293945,0.0001674741,0.000003324679,0.0005778696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009247247,"threshold_uncertainty_score":0.003093541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265194669107081,"score_gpt":0.2527649769527521,"score_spread":0.2401130302616813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}